Training Grant in Mechanisms of Vascular Disease

描述(由申请者提供)：本申请竞争续订血管疾病机制培训计划，将范德比尔特大学和梅哈里医学院血管生物学多学科研究的优势和多样性整合到一个连贯的计划中，以专门培训新的研究科学家。范德比尔特的参展部门包括生物化学、生物医学工程、癌症生物学、细胞和发育生物学、微生物学和免疫学、分子生理学和生物物理学、病理学、药理学、医学和儿科，以及Meharry的微生物致病和免疫反应以及神经生物学和神经毒理学。将在五个相互关联的不同研究领域提供培训 通过他们对血管生物学重要方面的关注。这些领域包括：(1)微生物血管疾病；(2)动脉粥样硬化、肥胖和高血压；(3)心血管发育和血管生成；(4)血管生成和组织重塑；(5)血栓和止血。这些定义广泛的研究领域侧重于提高对以下疾病潜在机制的认识(S)：导致心血管系统疾病的病毒、细菌或寄生虫感染；动脉粥样硬化及其与肥胖和高血压的关系；发育性和先天性心血管疾病及其修复；与肿瘤发生相关的血管生成以及细胞外基质和分子介质的作用；以及中风和心脏病发作中血栓形成的分子和细胞机制。每个重点领域由5至10名调查员组成。该项目将支持5名博士后和3名博士后(医学博士和/或博士)。实习生。博士前培训将导致获得一个基础科学学位。论文 研究将集中在培训资助导师的专门领域内的一个项目上。博士后培训将主要包括在培训补助金中的一名教师导师和一名共同导师的指导下进行实验室研究。所有博士后和博士后实习生将被要求参加这些课程。由参训教师讲授的血管疾病细胞和分子基础课程、科学传播基础课程、生物统计学课程，以及其他课程，视学员的背景和专业研究兴趣而定。受训人员还需要参加血管生物学和工作进展研讨会、年度血管生物学务虚会、选定的部门研究研讨会和负责任的研究行为培训。参与的教职员工的实验室里有充足的空间和最先进的仪器。

DESCRIPTION (provided by applicant): This application for competing renewal of the Training Program in Mechanisms of Vascular Disease integrates the strength and diversity of multidisciplinary research In vascular biology at Vanderbilt University and Meharry Medical College into a cohesive program for specialized training of new research scientists. Participating departments at Vanderbilt include Biochemistry, Biomedical Engineering, Cancer Biology, Cell & Developmental Biology, Microbiology & Immunology, Molecular Physiology & Biophysics, Pathology, Pharmacology, Medicine, and Pediatrics, and at Meharry, Microbial Pathogenesis and Immune Response and Neurobiology and Neurotoxicology. Training will be offered in five diverse areas of research, interconnected by their focus on significant aspects of vascular biology. The areas are: (1) Microbial Vascular Diseases; (2) Atherosclerosis, Obesity, and Hypertension; (3) Cardiovascular Development and Vasculogenesis; (4) Angiogenesis and Tissue Remodeling; and (5) Thrombosis and Hemostasis. These broadly defined research areas focus on advancing the understanding of the mechanism(s) underlying vascular diseases including; viral, bacterial, or parasitic Infections that commandeer the cardiovascular system to propagate disease; atherosclerosis and its relationship to obesity and hypertension; developmental and congenital cardiovascular diseases and their repair; angiogenesis associated with tumorlgenesis and the role of extracellular matrix and molecular mediators; and molecular and cellular mechanisms of thrombosis in stroke and heart attack. Each focus area consists of 5-10 investigators. The program will support 5 predoctoral and 3 postdoctoral (M.D. and/or Ph.D.) trainees. Predoctoral training will lead to a degree In one of the basic sciences. Dissertation research will focus on a project within the specialized area of a training-grant mentor. Postdoctoral training will consist primarily of laboratory research under the guidance of a faculty mentor from the training grant and a co-mentor. All predoctoral and postdoctoral trainees will be required to participate in the courses. Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, courses on Fundamentals of Scientific Communication, and Biostatistics, and other courses depending on the background and specialized research interests of the trainee. Trainees are also required to participate in the Vascular Biology and Workin- Progress Seminars, the annual Vascular Biology Retreat, selected departmental research seminars, and training in Responsible Conduct of Research. Ample space and state-of-the-art instrumentation are available in the laboratories of the participating faculty.