Administrative Core

该计划项目将在俄勒冈州立大学(OSU)莱纳斯·鲍林研究所(LPI)下正式统一，LPI下的计划项目住房提供了一个预先存在的组织结构来管理赠款，并促进与校园内具有联合研究兴趣的其他研究中心的科学互动。后者包括NIEHS资助的环境健康科学中心(EHSC)和基因组研究和生物计算中心(CGRB)。这一协调还提供了直接进入大学管理最高层的途径。 罗德里克·达什伍德是该计划项目的首席研究员，目前担任LPI癌症化学保护计划负责人、EHSC环境突变和癌症发生研究核心负责人以及环境和分子毒理学教授。达什伍德博士对Core B的监督将在高级办公室专家兼董事助理Barbara McVicar和客户经理Cathy Abney的协助下进行。 核心B将在所有申请和报告责任方面与NIH保持联系，包括汇编和提交NIH要求的所有报告和非竞争性续期，并获得人类受试者和脊椎动物的批准。该核心将直接管理所有三个项目和表观遗传/翻译生物标记物(ETB)核心的预算，协调定期安排的项目会议，并组织与外部咨询委员会(EAC)年度会议有关的所有活动。 EAC由约翰娜·W·兰佩博士、弗雷德·哈钦森癌症研究中心、伊利诺伊大学的威廉·赫尔费里奇博士和梅奥诊所的保罗·林堡博士组成。这个由杰出科学家组成的委员会已经发挥了指导调查人员准备这一竞争性延续工作的作用，根据他们的专业领域，对具体的项目要素进行审查并提出有益的建议。未来，EAC成员将评估研究进展，就计划项目如何最好地应对癌症化学预防领域的进展向PI和项目负责人提供建议，并与俄亥俄州立大学研究管理部门讨论促进此类反应可能需要的大学承诺。

This Program Project will be formally aligned under the Linus Pauling Institute (LPI) at Oregon State University (OSU), Housing of the Program Project under LPI provides a pre-existing organizational structure for administration of the grant, and for promoting scientific interaction with other research centers on campus with allied research interests. The latter include the NIEHS-funded Environmental Health Sciences Center (EHSC) and the Center for Genome Research and Biocomputing (CGRB). This alignment also provides direct access to the highest levels of university administration. Roderick Dashwood, the Principal Investigator of the Program Project, currently serves as Chief of the Cancer Chemoprotection Program in LPI, Leader of the EHSC Environmental Mutagenesis & Carcinogenesis research core, and Professor of Environmental & Molecular Toxicology. Dr. Dashwood's oversight of Core B will be carried out with assistance from Barbara McVicar, senior office specialist and Assistant to the Director and Cathy Abney, accounts manager. Core B will provide liaison with NIH in all application and reporting responsibilities, including compiling and submission of all reports and non-competing renewals required by NIH, and obtaining approvals of human subjects and vertebrate animals. This core will directly administer the budgets for all three Projects, and for the Epigenetic/Translational Biomarkers (ETB) Core, coordinate regularly scheduled Project meetings, and organize all activities associated with the annual External Advisory Committee (EAC) meetings. The EAC consists of Dr. Johanna W. Lampe, Fred Hutchinson Cancer Research Center, Dr. William Helferich, University of Illinois, and Dr. Paul Limburg, Mayo Clinic. This committee of distinguished scientists has already functioned to guide the investigators in the preparation of this competing continuation, with reviews and helpful suggestions pertaining to specific Project elements, according to their areas of expertise. In the future, EAC members will assess research progress, advise the PI and Project Leaders on how the Program Project may best respond to advances in the field of cancer chemoprevention, and discuss with OSU research administration the university commitments that may be necessary to facilitate such responses.