Male Contraception Research Center Grant

本应用中提出的工作旨在增加我们对男性生殖过程的基础和临床知识，特别是与避孕相关的知识。我们的工作重点是哺乳动物精子发生的生化、激素和遗传控制，包括在正常男性中的应用研究，目标是为全世界的男性开发新的、临床批准的避孕药。我们有四个研究项目：1)新型男性避孕ALDH1a2抑制剂（Dr. J. Amory， P.I.）；2)视黄醛脱氢酶作为男性避孕靶点（Dr. M. Griswold， P.I.）；3)精原干细胞自我更新与分化（Dr. R. Braun， P.I.）；4)男性激素避孕药对心血管疾病危险因素的影响（S. Page博士，P.I.）。我们还建议设立一个行政核心单位，其中包括一个研究员和新研究员计划。我们的提案将不同背景和专业训练的杰出研究人员的才能纳入生殖生物学的互动研究计划。我们建立这个中心是为了将精湛的科学与尽快将新的基础知识应用于人类研究的实际目标相结合。我们希望，通过这种方式，我们的工作将解决社会的关键需求。

The work proposed in this application is designed to increase our basic and clinical knowledge of reproductive processes in the male with particular relevance to contraception. The focus of our work is on the biochemical, hormonal and genetic control of mammalian spermatogenesis, including applied studies in normal men, with the goal of developing new, clinically approved contraceptives for men throughout the world. We have four research projects: 1) Novel ALDH1a2 Inhibitors for Male Contraception (Dr. J. Amory, P.I.); 2) Retinaldehyde Dehydrogenases as Male Contraceptive Targets (Dr. M. Griswold, P.I.); 3) Spermatogonial Stem Cell Self-Renewal and Differentiation (Dr. R. Braun, P.I.); and 4) Effects of Male Hormonal Contraceptives on Risk Factors for Cardiovascular Disease (Dr. S. Page, P.I.). We also propose an Administration Core Unit, which includes a Program for Fellows and New Investigators. Our proposal incorporates the talents of outstanding investigators of varied backgrounds and professional training into an interactive research program in reproductive biology. We have structured this Center to meld superb science with the practical goal of applying new basic knowledge as quickly as possible to studies in human beings. We hope that, in this way, our work will address critical needs of society.