Chemosensory pathways in food intake

随着西方饮食的传播，全球肥胖症的发病率继续上升 许多与肥胖相关的疾病也相应增加。在导致肥胖的所有原因中， 最主要的似乎是选择--选择吃得更多，锻炼得更少。其中一个选择是 与肥胖联系在一起的是选择高脂肪、高热量的饮食。最近的研究表明 研究表明，脂肪酸是味觉、消化、躯体感觉和中枢的典型脂肪刺激。 神经系统。这项提案试图跟进有趣的观察结果，这些观察结果显示，在老鼠身上， 脂肪酸信号通路中的重要成分导致脂肪摄入量和伴随的脂肪减少 减少体重和体脂。在这两年的探索性提案中，我们将尝试区分(1) 特定脂肪酸信号成分对膳食脂肪摄入量和身体成分的影响；(2) 摄食前或摄食后的信号有助于控制脂肪摄入量和(3)任何 食物摄入量的变化与异常的脂肪酸信号有关。理解化学感觉的作用 对控制营养摄入的信号知之甚少，而且发现一种特定的 化学感觉通路改变饮食脂肪摄入量仍是高度新颖的，对控制仍有潜在的重要意义 饮食导致的肥胖。

The incidence of obesity worldwide continues to escalate with the spread of the Western diet and with it there has been a corresponding increase in numerous obesity-related disorders. Of all the causes for obesity, the predominant one seems to be choice - the choice to eat more and exercise less. One of the choices that has been linked with obesity has been the selection of a high fat, calorically dense diet. Recent research has shown that fatty acids are the prototypical fat stimulus in the gustatory, digestive, somatosensory and central nervous systems. This proposal seeks to follow up on interesting observations that show in mice deletions in important elements in the fatty acid signaling pathway lead to decreases in fat intake and concomitant reductions in body weight and body fat. In this two year exploratory proposal we will attempt to discern (1) the effect specific fatty acid signaling components have on dietary fat intake and body composition; (2) whether pre- or post-ingestive signaling contributes to the control of fat intake and (3) the nutrient specificity of any changes in food intake associated with aberrant fatty acid signaling. Understanding the role of chemosensory signals in the control of nutrient intake is poorly understood and the finding that alterations in a specific chemosensory pathways alters dietary fat intake remains highly novel and potentially important for the control of dietary-induced obesity.