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Akt Signaling at the Crossroads of Depression and Addiction

Akt Signaling at the Crossroads of Depression and Addiction
Akt 信号在抑郁和成瘾的十字路口
批准号:
8679536
负责人:
THOMAS F FRANKE
金额:
$20.45万
依托单位国家:
美国
项目类别:
财政年份:
2013
资助国家:
美国
项目状态:
已结题
起止时间:
2013-11-15 至 2015-06-30
关键词:
1-Phosphatidylinositol 3-KinaseAKT1 geneAddictive BehaviorAddressAffectAgeAnimalsAntipsychotic AgentsAreaAutistic DisorderBasic ScienceBehaviorBehavioralBehavioral ParadigmBiologicalBiological MarkersBrainBreedingCell physiologyCellsChronic stressClinicalClinical TreatmentCocaineCodeComorbidityConsultDecision MakingDevelopmentDisastersDiseaseDopamineDopamine D2 ReceptorDopamine ReceptorDrug usageDry IceEmergency SituationExtinction (Psychology)FloodsFloorFreezingGeneticGenetic ModelsGenetic VariationGenotypeGoalsHealthcareHeart DiseasesHomologous GeneHospitalsHousingHumanInstitutesLaboratoriesLaboratory ResearchLinkLiquid substanceLocationMalignant NeoplasmsMechanicsMediatingMedicalMedical centerMental DepressionModelingMolecularMoodsMotivationMusMutant Strains MiceNeuronsNeurosciencesNew York CityNitrogenPathway interactionsPatient CarePatientsPhasePhosphorylationPhosphotransferasesPlayPlumbingPredispositionProtein-Serine-Threonine KinasesPsychiatryReagentReceptor ActivationReceptor SignalingRecoveryRegulationReportingResearchRewardsRisk AssessmentRisk FactorsRodentRoleSafetySamplingSchizophreniaScienceSerotonin Receptor 5-HT1ASignal PathwaySignal TransductionSiteStressSystemVendoraddictioncongenicdesigndopamine systemdopaminergic neurondrug of abuseexperienceextracellularhospital patient careimprovedinnovationinsightmedical schoolsneuropsychiatrynoveloperationpreferenceprogramspromoterpsychostimulantreceptorrecombinaserepairedresearch studyresponserestorationserotonin receptorsexsocial

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中文摘要
翻译
2012年10月29日,纽约大学朗格尼医疗中心遭遇了一场前所未有的风暴,造成了破坏 这对我们的病人护理、研究和教育设施产生了深刻的影响。NYULMC的应急电源 系统是根据所有安全规范设计和建造的,能够承受比最高洪水更高的浪涌 在过去的一个世纪里,纽约市的水平。超级风暴桑迪显然超过了这些级别。虽然我们 从Tisch医院和Schwartz医疗中心安全疏散了300多名患者 在风暴中,我们的主校区的机械、电气和管道系统遭到了广泛的破坏, 要求暂时关闭我们的主校园。我们现在正处于灾后恢复期,解决 风暴造成的损失,并评估缓解需求。 有三座基础科学大楼,Skirball研究所,Smilow研究中心和医学中心 科学大楼(MSB)。更多的基础科学实验室被安置在专门的区域,包括Dr。 弗兰克的实验室在5楼,是米尔豪泽实验室的一部分。其中三个的地下水平 这些建筑、斯米洛研究中心、Tisch医院和MSB遭到严重破坏。这只动物 斯米洛的间隔症被认为是完全无法恢复的。来自MSB间隔室的动物被重新安置到 卫星设施。尽管许多人做出了英勇的努力,从斯米洛手中救出了一些啮齿动物 研究中心,许多人仍然死亡,包括用于心脏研究的基因改变的品系 疾病、癌症、自闭症和精神分裂症。斯基博尔研究所和斯米洛研究中心 11月12日投入使用;然而,MSB遭受了最广泛的破坏,修复工作正在进行中。 MSB的恢复将导致从今年夏天开始分阶段恢复运营。研究 Tisch医院的实验室,包括Franke博士的实验室都搬迁到了新的地点,以便 促进Tisch医院的重新开放,以照顾病人。 由于电力中断和冰柜故障,大量冷藏和冷冻的生物检验品和 试剂丢失了。尽管有这些损失,许多样本还是通过运输干冰和液体保存了下来 将氮气运往受影响地区,直到样品可以被转移到场外冷藏供应商设施为止。
英文摘要
NYU Langone Medical Center experienced an unprecedented storm on October 29th, 2012, causing damage that deeply impacted our patient care, research, and educational facilities. NYULMC’s emergency power system was designed and built according to all safety codes to withstand a surge higher than the highest flood level for New York City in the past century. Superstorm Sandy obviously exceeded those levels. Although we safely evacuated over 300 patients from Tisch Hospital and Schwartz Health Care Center (HCC) in the midst of the storm, our main campus incurred extensive damage to its mechanical, electrical, and plumbing systems, requiring the temporary closure of our main campus. We are now in a post-disaster recovery period addressing the damage caused by the storm and assessing mitigation needs. There are three basic science buildings, the Skirball Institute, the Smilow Research Center, and the Medical Science Building (MSB). Additional basic science laboratories were housed in dedicated areas including Dr. Franke’s laboratory on the 5th Floor as part of the Milhauser Laboratories. The below-ground levels of three of these buildings, the Smilow Research Center, Tisch Hospital and MSB were significantly damaged. The animal vivarium of Smilow was deemed completely unrecoverable. Animals from the MSB vivarium were relocated to satellite facilities. Despite the heroic efforts of many that saved a number of rodents from the Smilow Research Center, many still perished, including lines that were genetically altered for use in the study of heart disease, cancer, autism and schizophrenia. The Skirball Institute and the Smilow Research Center were operational by November 12th; however, MSB sustained the most extensive damage, and repairs are ongoing. The restoration of MSB will result in a phased return of operations beginning this summer. Research laboratories in Tisch Hospital including Dr. Franke’s laboratory were relocated to new locations in order to facilitate the reopening of Tisch Hospital for patient care. Due to disruptions in power and freezers failing, a large number of refrigerated and frozen biospecimens and reagents were lost. Despite these losses, many samples were saved by transporting dry ice and liquid nitrogen to affected areas until the samples could be relocated to an off-site cryostorage vendor facility.
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Akt Signaling at the Crossroads of Depression and Addiction
Akt Signaling at the Crossroads of Depression and Addiction