Mentoring Clinical and Translational Patient-Oriented Research in Staphylococci

描述（由申请人提供）：自从十年前完成临床培训以来，我的研究一直集中在这个问题上，“为什么有些金黄色葡萄球菌感染的患者表现良好，而其他人表现不佳？“最近，作为一名物理学家和科学家，我走到了一个明显的十字路口。我已经建立了一个研究基础设施，这是资金充足，并有广泛的研究活动。在重点研究S.金黄色葡萄球菌，它跨越从生物体的发病机制的基础科学，宿主的遗传易感性，直接疾病的临床特征。我所处的机构环境使我能够利用其大量的培训和受训人员资源。我还展示了一个跟踪记录，在提供指导各种各样的开始研究人员。出于这些原因，我认为获得K24对我来说至关重要，这样我就可以专注于研究及其指导，避免医生/科学家在临床上过度投入的常见陷阱。因此，本提案的总体目标是通过培训下一代临床医生-科学家在葡萄球菌的临床和转化患者导向研究中提高我的指导技能。指导技能不是与生俱来的;它们可以而且应该是学习的。我将通过几种方式发展我的指导专长。首先，我的指导进度将接受由高级研究人员和导师组成的咨询委员会的定期正式审查。接下来，我将创建“指导中期职业导师计划”。与上述高层投入相比，该计划将采取“对等”的方式，通过将杜克职业生涯中期的K24接受者聚集在一起，讨论共同的指导问题，来指导技能发展。最后，我将通过参与杜克CTSA的国家指导小组委员会，参与国家一级的指导。作为科学家，我将通过追求两个具体目标来促进我的指导计划，这两个目标结合了我的研究平台的广度。每个目标包括几个不同的项目，重点是以患者为导向的葡萄球菌研究。这些项目将作为验证假设的科学，巩固我的指导计划。具体目标1，指导葡萄球菌的临床患者导向研究，将通过3个单独的项目来完成：一个项目侧重于导管相关葡萄球菌菌血症治疗算法的随机、多国试验，另外两个项目采用葡萄球菌感染的大型临床数据库。具体目标2，指导翻译的葡萄球菌患者为导向的研究，将通过追求几个项目涉及细菌和宿主的遗传决定因素的葡萄球菌。金黄色葡萄球菌感染。我的长期目标是建立一个多学科的计划，重点是临床和翻译葡萄球菌的POR。通过扩大我的研究计划的广度，K24将促进我实现这一目标的进展，并将有助于为下一代临床科学家做好准备，以应对这种持久的病原体。 该提案与公共卫生的相关性：K24提案与美国公众的健康高度相关，因为它旨在为下一代临床科学家做好准备，以对抗金黄色葡萄球菌。S.金黄色葡萄球菌是困扰美国公众的主要病原体之一。S.金黄色葡萄球菌正在增加。对临床分离的S.金黄色葡萄球菌分离株对可用抗生素的耐药性表明病原体对所有目前批准的治疗具有耐药性的可能性。该提案旨在通过指导年轻的研究人员进行葡萄球菌的临床和转化患者导向研究来提高我们对这种持久性病原体的理解。

DESCRIPTION (provided by applicant): Since the completion of my clinical training a decade ago, my research has focused on the question, "Why do some patients with Staphylococcus aureus infection do well, while others do poorly?" Recently, I have come to a distinct crossroad as a physician-scientist. I have erected a research infrastructure which is well-funded and has a breadth of research activities. While focused on S. aureus, it spans from the basic science of the organism's pathogenesis, to host genetic susceptibility, to direct clinical features of disease. I am in an institutional environment which allows me to tap into its substantial resources of training and trainees. I have also demonstrated a track record in providing mentorship to a wide variety of beginning researchers. For these reasons, I believe it is critically important for me to earn a K24 so I can focus on research and its mentoring and avoid the common pitfall of the physician/scientist who becomes clinically overcommitted. Thus, the overall goal of this proposal is to improve my mentoring skills by training the next generation of clinician-scientists in clinical and translational patient oriented research in the staphylococci. Mentoring skills are not innate; they can and should be learned. I will develop my mentoring expertise in several ways. First, my mentoring progress will receive regular formal review from an Advisory Board of senior researchers and mentors. Next, I will create the "Mentoring Mid-Career Mentors Program". In contrast to the senior-level input outlined above, this program will pursue a "peer to peer" approach to mentor skills development by bringing together Duke's mid-career K24 recipients to discuss common mentoring issues. Finally, I will participate in mentoring on a national level by involvement in the National Subcommittee on Mentoring of the Duke CTSA. Scientifically, I will facilitate my mentoring plan by pursuing two Specific Aims that incorporate the breadth of my research platform. Each Aim includes several distinct projects focused on patient oriented research of staphylococci. These projects will serve as the hypothesis-testing science that undergirds my mentoring plan. Specific Aim 1, mentoring clinical patient oriented research in staphylococci, will be accomplished by pursuing 3 individual projects: one project focused on a randomized, multinational trial of a treatment algorithm for catheter-related staphylococcal bacteremia, and two other projects employing large clinical databases of staphylococcal infections. Specific Aim 2, mentoring translational patient-oriented research in staphylococci, will be accomplished by pursuing several projects involving bacterial and host genetic determinants of S. aureus infection. My long-term objective is to create a multidisciplinary program that focuses on clinical and translational POR of staphylococci. By expanding the breadth of my research program, a K24 would enhance my progress towards this goal, and would help to prepare the next generation of clinician-scientists to confront this persistent pathogen. RELEVANCE OF THIS PROPOSAL TO PUBLIC HEALTH: This K24 proposal is highly relevant to the health of the American Public, as it aims to prepare the next generation of clinician-scientists to confront Staphylococcus aureus. S. aureus is one of the leading pathogens plaguing the American public. Rates of both infections and antibiotic resistance in S. aureus are increasing. The identification of clinical S. aureus isolates resistant to available antibiotics indicates the possibility of a pathogen resistant to all currently approved therapy. This proposal seeks to improve our understanding of this persistent pathogen by mentoring young investigators in clinical and translational patient oriented research of staphylococci.