ADVANCING LOCOMOTION AND DEVELOPMENT IN YOUNG CHILDREN WITH DOWN SYNDROME

项目摘要/摘要 这项临床研究计划的总体目标是为婴儿提供 唐氏综合症(DS)的训练和技术，以独立探索他们的 与其典型的发展中同龄人一样，在世界上也是如此。移动和移动性 占幼儿醒着时间的80%。如此高剂量的坐着、站着 步行是儿科康复的崇高黄金标准。唐氏综合征(DS)， 它将坐、站和走路的时间推迟了长达一年，大大减少了婴儿每天的 具有严重的认知、语言和社会后果的探索。这项建议 专门测试一种新的“移动治疗环境”的可行性和效果。 集动力移动、渐进式运动和功能技能培训于一身 技术设备。 我们改装后的汽车骑行特别结合了电动移动性的乐趣和探索 (例如赛格威)能够通过以下方式提高平衡性、强度和协调性 在婴儿练习坐、站和走路的同时进行治疗性练习。在过去一年里， 我们已经开发了一系列的电气和机械改进，使一辆汽车 坐着逐步驾驶，然后站立触发安全驾驶(图1 上)，然后由地面行走触发(图1下)。 这项建议将使我们能够确定在汽车上进行骑行训练的可行性和效果 坐、站和行走延迟(目标1)以及婴儿更广泛的认知、语言和 社会-情绪发展(目标2)。这项建议的灵感来自于我们的移动机器人工作 并由初步数据支持，是科学的原则性的，创新的，但在 资助期。这个为期2年的项目中的数据和设备将支持更正式的工作 一种新的辅助技术的临床和商业潜力：移动 治疗环境‘。 图1改装后的平顺性 玩具车提供 物美价廉 流动性和社会化 在加强的同时， 平衡、协调 一边开车一边开车 站立(上)和 边走边开车 (较低)。

PROJECT SUMMARY/ABSTRACT The overall goal of this clinical research program is to provide infants with Down syndrome (DS) with the training and technology to independently explore their world to the same degree as their typically developing peers. Moving and mobility comprise up to 80% of a young child's waking hours. Such a high dose of sitting, standing and walking are a lofty gold standard for pediatric rehabilitation. Down syndrome (DS), which delays sitting, standing and walking by up to a year, significantly reduces infants' daily exploration with serious cognitive, language, and social consequences. This proposal specifically tests the feasibility and effects of a novel 'mobile therapy environment' that provides powered mobility, progressive exercise and functional skills training in one assistive technology device. Our modified ride on cars specifically combine the fun and exploration of powered mobility (such as a Segway) with the ability to advance balance, strength and coordination through therapeutic exercises while infants practice sitting, standing and walking. Over the last year, we have developed a series of electrical and mechanical modifications that allow a single car to be progressively driven in sitting, then safely driven as triggered by standing (Figure 1 upper) then triggered by over ground walking (Figure 1 lower). This proposal will allow us to determine the feasibility and effect of ride on car training on sitting, standing and walking delays (Aim 1) and on infants' broader cognitive, language and social-emotional development (Aim 2). This proposal, inspired by our mobile robotics work and supported by preliminary data, is scientifically principled, innovative yet feasible within the funding period. The data and devices from this 2 yr project will support more formal work on the clinical and commercial potential of a novel category of assistive technology: the 'mobile therapy environment'. Figure 1 Modified ride on toy cars provide inexpensive effective mobility and socialization as well as strengthening, balance, coordination during driving while standing (Upper) and driving while walking (Lower).