Sleep-wake disturbances and physical and psychological health in adolescents with

描述(申请人提供)：在过去的十年里，越来越多的证据表明，睡眠障碍和障碍与青少年的身心健康有着千丝万缕的联系。然而，很少有研究将睡眠作为一种可改变的机制来研究，这种机制可能会改善医疗康复和心理健康治疗，并为患有慢性肢体残疾的青少年弱势群体的健康政策提供信息。特别是，患有脊柱裂(SB)的青少年面临着一系列 情绪和认知困难，包括抑郁和注意力缺陷，以及严重的功能障碍。睡眠-唤醒障碍，如入睡困难、夜间频繁唤醒和白天过度疲劳，在患有慢性病和神经障碍的年轻人中尤其普遍。然而，很少有研究考虑睡眠障碍对患有SB的青少年的身心健康的有害影响。因此，本项目的目的是：1)使用主观和客观的睡眠测量方法全面检查SB青少年的睡眠-觉醒模式；2)确定SB青少年睡眠-唤醒障碍与生理和心理功能之间的关系；3)确定SB青少年睡眠和情绪之间的日常时间联系。这项研究将检查12至17岁患有SB的青少年(N=40)的睡眠-觉醒模式，并与典型发育同龄人(N=40)的匹配对照组进行比较。将进行主观和客观的睡眠评估；将在10天内完成动态活动记录，青少年将完成几个睡眠问卷(例如，睡眠质量、睡前唤醒)和每日睡眠日记。此外，青少年和父母将接受半结构诊断性访谈和完整的症状问卷，以评估抑郁和注意力缺陷，以及与健康相关的生活质量。从这项研究中获得的知识将是阐明可改变的继发性条件以改善患有SB的慢性肢体残疾青少年的身心健康结果的第一步，并为申请者提供研究培训，以制定这一领域的独立研究计划

DESCRIPTION (provided by applicant): In the past decade, an increasing body of evidence has indicated that sleep disturbances and disorders are intricately connected to adolescent physical and mental health. However, there is a paucity of research that has investigated sleep as a modifiable mechanism that may improve medical rehabilitation and mental health treatments and inform health policies in vulnerable populations of adolescents with chronic physical disabilities. In particular, adolescents with spina bifida (SB) are at-risk for a range of emotional and cognitive difficulties, including depression and attention deficits, as well as significant functional impairment. Sleep- wake disturbances, such as difficulty falling asleep, frequent nighttime awakenings, and excessive daytime fatigue, are especially prevalent in youth with chronic illnesses and neurological disorders. However, few studies have considered the deleterious impact of disturbed sleep on physical and psychological health in adolescents with SB. Thus, the aims of this project are to 1) comprehensively examine sleep-wake patterns in adolescents with SB using subjective and objective measures of sleep, 2) identify the relationship between sleep-wake disturbances and physical and psychological functioning in adolescents with SB, and 3) identify daily temporal associations between sleep and mood in adolescents with SB. This study will examine sleep- wake patterns in adolescents ages 12 to 17 with SB (N = 40) compared to a matched comparison group of typically developing peers (N = 40). A subjective and objective sleep assessment will be conducted; ambulatory actigraphic recordings will be completed over 10 days, and adolescents will complete several sleep questionnaires (e.g., sleep quality, pre-sleep arousal) and a daily sleep diary. In addition, adolescents and parents will undergo a semi-structured diagnostic interview and complete symptom questionnaires to assess depression and attention deficits, and health-related quality of life. Knowledge gained from this study will be the first step in elucidating modifiable secondary conditions to improve physical and mental health outcomes in chronically physically disabled adolescents with SB, and provide the applicant with research training to develop an independent research program in this area