Porous, Patient Specific Interbody Fusion Cages with Enhanced Loading Characteris

项目摘要 这项拟议的研究将通过以下方式挑战腰椎间融合术的标准方法 利用医学成像、有限元(FE)模型和新兴材料来指导新型设备设计。 这些融合术每年为50万名患有退行性腰椎间盘疾病的患者进行， 不稳定和脊柱侧弯。这一提议为研究LIF提供了一种创新的、多学科的方法。 传统的CT将被关联并用于预测局部强度和模量值 端板。这些数据还将用于创建具有匹配材料的特定于患者的FE模型 属性。有限元模拟将被用来评估脊柱的复杂生物力学 保持架/杆的设计、材料和配置。此外，模拟将产生有价值的信息 将终板上的应力分布和整体结构刚度视为骨的函数 形成和融合。最后，聚对苯系物(Ppps)是一类新型的高强度芳香族聚合物。 模量值高于聚醚醚酮(PEEK)。PPP具有优越的可制造性 与目前的保持架材料相比，将制成多孔性装置。该装置的孔隙率将是 在空间上量身定做以匹配端板上的植入物的特性，同时还促进 骨的骨结合。我们的假设是，一个多孔的椎间融合器可以减少并发症。 (下沉和邻近节段疾病)，并通过(1)空间定制的模数来改善临床结果 植入到终板上，(2)在整个终板上更均匀地分布应力，(3)降低 整体构造刚性值，以及(4)允许骨与种植体的骨结合。如果成功， 拟议中的研究将改变LIF笼子和构造的设计以及 较低的下沉、种植失败和邻近节段疾病的发生率。拟议的团队由一名内部 具有临床外科、机械和生物医学工程背景的学科小组，以及 材料科学。

Project Summary The proposed research will challenge the standard approach to lumbar interbody fusions (LIFs) by utilizing medical imaging, finite-element (FE) models and emerging materials to guide novel device design. These fusions are performed annually on 500,000 patients who suffer from degenerative disc disease, instability, and scoliosis. This proposal offers an innovative, multi-disciplinary approach to studying LIFs. Conventional CT will be correlated and utilized to predict local strength and modulus values across the endplates. These data will also be used to create patient-specific, FE models with the matching material properties. FE simulations will be used to evaluate the complex biomechanics of the spine for a wide variety of cages/rod designs, materials, and configurations. Furthermore, simulations will yield valuable information regarding the stress distribution across the endplates as well as overall construct stiffness as a function of bone formation and fusion. Lastly, poly(para-phenylenes) (PPPs) are a new class of aromatic polymers with strength and modulus values higher than poly(ether-ether-ketone) (PEEK). PPPs have superior manufacturability compared to current cage materials and will be made into porous devices. The porosity of the device will be spatially tailored to match the properties of the implant across the endplates, while also promoting osteointegration of bone. Our hypothesis is that a porous interbody fusion cage would reduce complications (subsidence and adjacent-level disease) and improve clinical outcomes by (1) spatially tailoring the modulus of the implant to the endplate, (2) more evenly distributing stresses across the entire endplate, (3) lowering the overall construct stiffness value, and (4) allowing for osteointegration of bone into the implant. If successful, the proposed research would shift the paradigm for how LIF cages and constructs are designed as well as lower rates of subsidence, implant failures, and adjacent-level disease. The proposed team consists of an inter- disciplinary group with backgrounds in clinical surgery, mechanical and biomedical engineering, and materials science.