New Frontiers In Tendon Research

描述（由申请人提供）：肌腱疾病，包括肌腱病和肌腱断裂，是常见的致残性肌肉骨骼疾病。尽管肌腱损伤的患病率，有效的干预和预防的治疗措施取得了进展，但成功有限，因为缺乏数据描述的基本机制，有效的肌腱功能和对损伤的反应。越来越明显的是，有必要增加对肌腱的研究。肌腱领域相对于其他肌肉骨骼组织（如骨和软骨）的进展较慢，部分原因可能是肌腱领域相对年轻，只有少数研究人员从事基础力学研究。 提供一个专门的论坛，以增加肌腱领域研究者社区内的合作和沟通，将产生协同效应，使高影响力的研究比个人研究者所能实现的更大。此外，对于一个新兴领域来说，借鉴其他相关领域取得的进展和积累的专门知识是必不可少的。建立和利用肌腱领域以外的专家的优势将使肌腱研究人员能够扩大自己的研究，从而促进肌腱领域的发展。 此外，这种交叉施肥的方法可以吸引年轻的研究人员和学员从其他领域进入肌腱研究。我们建议组织一次会议，创造一个有利于在肌腱领域内发起新的合作的环境，并与肌腱领域以外的专家进行合作。因此，拟议的会议将有一个新的形式，特别是有针对性的，以促进初级和既定的研究人员之间的合作，在该领域和专家从肌腱领域以外。来自肌腱领域内外的专家被选中领导关于六个基本主题的分组讨论。会议领导人之间的协作努力所产生的有指导的讨论将确保有一个广泛的视角。为了鼓励在会议上进行积极的讨论，每个主题将在“分组”会议期间与不同的与会者进行多次讨论。通过继续互动和出版关于每个专题的文稿，会议产生的势头及其影响将在会议结束后继续下去。每份手稿将反映所表达的广泛观点，并突出每个主题的已知和未知内容。我们期望通过这种会议形式进行新颖和高效的合作，促进肌腱研究领域的预期进展。

DESCRIPTION (provided by applicant): Tendon diseases, including tendinopathy and tendon rupture, are common and disabling musculoskeletal conditions. Despite the prevalence of tendon injuries, therapeutic measures for effective intervention and prevention have progressed with limited success because of the paucity of data describing the basic mechanisms that underlie effective tendon function and response to injuries. It is becoming more apparent that there is a need for an increase in tendon research. The slower progress of the tendon field relative to that of other musculoskeletal tissues, such as bone and cartilage, may be in part attributable to the relatively young age of the tendon field with a small number of investigators engaged in fundamental mechanistic research. Providing a dedicated forum for increasing collaborations and communications within the community of investigators in the tendon field will create synergies allowing high impact research greater than that achievable by individual investigators. In addition, it is integral for an emerging field to build on progress and incorporae expertise from other related fields. Building on and leveraging strengths of experts from outside the tendon field will allow tendon researchers to expand their own research resulting in growth of the tendon field. Furthermore, this cross-fertilization approach may serve to attract young investigators and trainees from other fields into tendon research. We propose to organize a meeting that creates an environment that is conducive for initiating novel collaborations within the tendon field and with experts from beyond the tendon field. As such, the proposed meeting will have a novel format that is particularly targeted to promote collaborations between junior and established investigators within the field and with experts from beyond the tendon field. Experts from within and outside the tendon field have been chosen to lead discussions in breakout sessions on six essential topics. The guided discussion that results from the collaborative effort between the session leaders will ensure a wide perspective. To encourage active discussion at the meeting, each topic will be discussed multiple times with different participants during 'breakout' sessions. The momentum gained from the meeting and its impact will be continued beyond the time of the meeting, through continued interactions and publication of manuscripts on each topic. Each manuscript will reflect the broad views expressed and highlight what is known and what remains unknown for each topic. We expect that novel and highly effective collaborations will ensue from this meeting format, promoting the desired advancement in the field of tendon research.