Interdisciplinary Training in Rheumatic Diseases

描述（由申请人提供）：本申请为范德比尔特大学风湿病学和免疫学部门申请新的机构国家研究服务奖（T32）。在范德比尔特大学，由医学系领导的生物医学研究在最近十年中经历了前所未有的增长。这一扩张伴随着风湿病科的重建和发展。风湿病学部门的研究人员已经产生了非常成功的临床和基础科学研究项目，这些项目伴随着强大和多样化的临床实践。在这种环境下，由于最近将分子机制转化为治疗的进展，寻求风湿病研究职业的学员在各个层面都有所增加。因此，一个新的培训计划将提供一个未满足的需求，在风湿病的研究培训，为优秀的前和博士后学员。没有其他医学学科像风湿病一样包含如此多的不同器官系统或具有如此多的病理生理学。因此，提出了风湿病跨学科培训计划，该计划将为下一代研究人员提供必要的工具，以做出关键发现，并推进我们对这些复杂疾病的理解和治疗。我们的教师致力于实现这一目标，我们在没有正式支持的情况下培养出杰出的博士研究员和医师科学家的成功证实了这一承诺。该计划将保持一个互动的发现环境，在四个关键领域为博士后和博士生的临床和基础研究架起桥梁：先天和适应性免疫；血管生物学与炎症；转化和保健服务研究；肌肉骨骼生物学。该计划中的导师是高度互动的，并在研究小组之间保持广泛的合作努力。这种跨学科的方法将为受训者提供一个广阔的视角，并使他们有机会对单个实验室无法解决的问题进行临床翻译。MSCI和MPH的个人发展计划、正式课程作业和学位授予途径将通过核心课程获得。该计划旨在满足那些希望将基因组学或蛋白质组学等先进技术应用于风湿病的个人的职业目标，并支持那些希望将这些进步转化为改善医疗保健的个人的职业目标。有适当的机制来确保学员选择和长期职业发展的平衡和多样性。优秀的内部和外部咨询委员会将确保实现这些目标。

DESCRIPTION (provided by applicant): This application requests a new Institutional National Research Service Award (T32) for the Division of Rheumatology and Immunology at Vanderbilt University. Biomedical research at Vanderbilt led by the Department of Medicine has undergone unprecedented growth in the recent decade. This expansion was accompanied by rebuilding and growth in the Rheumatology Division. Investigators in the Division of Rheumatology have generated highly successful clinical and basic science research programs and these accompany a robust and diverse clinical practice. In this environment, and as a consequence of recent advances translating molecular mechanisms into therapy, trainees seeking careers in rheumatology research have increased at all levels. Thus, a new training program will provide an unmet need for research training in rheumatic diseases for an outstanding pool of pre and postdoctoral trainees. No other discipline in medicine encompasses as many different organ systems or has the diversity of pathophysiology as do rheumatic diseases. Accordingly, a plan is proposed for Interdisciplinary Training in Rheumatic Diseases that will provide the next generation of investigators with the tools necessary to make critical discoveries and advance our understanding and treatment of these complex disorders. Our faculty is committed to this goal and our successes in producing outstanding PhD investigators and physician-scientists without formalized support confirm this commitment. The program will maintain an interactive environment of discovery that bridges both clinical and basic research for pre and postdoctoral trainees in four critical arenas: Innate and Adaptive Immunity; Vascular Biology and Inflammation; Translational and Health Services Research; and Musculoskeletal Biology. The Preceptors in the program are highly interactive and maintain extensive collaborative efforts between and among the research groups. This interdisciplinary approach will provide trainees with a broad perspective and expose them to opportunities for clinical translation of problems that cannot be solved by a single laboratory. Individual development plans, formal course work and degree granting pathways for MSCI and MPH will be accessed through a core curriculum. The program is organized to meet the career goals of individuals who want to apply advanced technologies, such as genomics or proteomics, to rheumatic diseases as well as to support the careers of individuals who want to translate these advances to improve health care. Mechanisms are in place to ensure the balance and diversity of trainee selection and long term career development. Outstanding internal and external Advisory committee's will ensure these goals are met.