Training in Tissue Engineering and Regenerative Medicine

描述(申请人提供)：组织工程与再生医学培训计划更新的重点是为博士生提供生物医学研究方面的高级培训。该计划的教学部分提供了一种综合的、创新的和严格的教育体验，其目标是修复或再生人体组织和器官，并保持人类健康的质量。该项目的资源来自托马斯·杰斐逊大学几个系/科的资金充足的核心教员，包括整形外科、皮肤科、内科、外科、解剖学和发育生物学、干细胞生物学、病理学和细胞生物学以及罗斯曼研究所。我们要求在01-03年度资助5名博士前学生，并在04-05年度资助6名博士后学生。该计划有六个目标：(1)整合细胞、分子和发育生物学的当代进展以了解组织功能；(2)将生命科学的基本进展与组织工程的当代问题联系起来；(3)促进对骨骼疾病的病理生理学的实际理解；(4)通过与临床和外科医生的密切合作来开发翻译研究；(5)通过与生物技术行业的科学家互动来实施翻译研究；(6)为肌肉骨骼研究的职业生涯建立人才管道。培训计划的教学方面嵌入了发育、细胞和分子生物学的整合；生物信息学和功能基因组学；组织工程和生物成像；以及转化医学。为了在人类疾病上扎根，临床医生在每一门主要课程中讲课。通过经常与治疗疾病蹂躏的外科医生互动，通过在诊所和手术室直接观察和与教师讨论，学生们培养了对组织工程学和再生医学可以治疗的健康问题的欣赏。通过与当地生物技术公司和实验室的科学家合作，进一步推动了转化研究的发展。在此背景下，学生开展学位论文研究，为他们未来作为独立、创新的科学研究人员的职业生涯奠定了基础。

DESCRIPTION (provided by applicant): The focus of the renewal of the Training Program in Tissue Engineering and Regenerative Medicine is to provide doctoral students with advanced training in biomedical research. The didactic portion of the Program provides an integrated, innovative and rigorous educational experience that has as its goal the repair or regeneration of human tissues and organs and the preservation of the quality of human health. Resources for the program come from a core of well-funded faculty in several departments/divisions at Thomas Jefferson University including Orthopaedic Surgery, Dermatology, Medicine, Surgery, Anatomy and Developmental Biology, Stem Cell Biology, Pathology and Cell Biology and the Rothman Institute. We request support for five predoctoral students in the 01-03 year of the grant and six students in the 04-05 years. There are six program objectives: (1) to integrate contemporary advances in cell, molecular, and developmental biology towards understanding tissue function; (2) to relate fundamental advances in the life sciences to contemporary issues in tissue engineering (3) to foster practical understandings of the pathophysiology of diseases of the skeleton; (4) to develop translational research by working closely with physicians in a clinical and surgical setting; (5) to implement translational research through interactions with scientists in the biotech industry and (6) to build a pipeline of talented individuals for careers in musculoskeletal research The didactic aspects of the training program are embedded in integrating developmental, cell and molecular biology; bioinformatics and functional genomics; tissue engineering and bioimaging; and translational medicine. So as to anchor the program in human disease, clinicians lecture in each of the major courses. By interacting frequently with surgeons who treat the ravages of disease, and by direct observation and discussion with faculty in the clinic and operating room, students develop an appreciation for health problems that are amenable to treatment by tissue engineering and regenerative medicine. Development of translational research is furthered by collaboration with scientists at local biotech companies and laboratories. Against this background, students develop their dissertation research which provides the foundation for their future careers as independent, innovative scientific investigators.