Biomarker Research in Musculoskeleton Disease

描述(由申请人提供)：骨质疏松症是老年男性和女性的一个重要问题。最近的研究表明，骨骼生物标记物可能提供有关骨质疏松症的生物原因的重要信息，并可能对单独预测骨折或与其他危险因素结合时有用。加州大学旧金山分校医学、流行病学和生物统计学教授道格拉斯·鲍尔博士要求延长他在面向患者的研究中获得的K24职业中期研究员奖，他的科学目标是使用具有良好特征的老年男性纵向队列(MRO)的数据开发新的、临床上有用的蛋白质组生物标志物。利用正在进行的骨折评估和最近在基线收集的血清蛋白质组测量资金，这项研究将探索3000名MRO参与者的蛋白质组特征与脊柱骨折事件之间的预期关系。鲍尔博士长期隶属于旧金山协调中心，他将利用这些和其他来自多项大型研究的数据，继续指导对临床研究感兴趣的年轻研究人员，尤其是住院医生。通过最初的K24奖项，鲍尔博士指导了目前正在从事更多研究、培训和学术事业的住院医生和研究员。与加州大学旧金山分校临床和翻译科学研究所合作，在最初的K24奖项期间，他还开发并指导了一个新的综合驻地研究计划。这一新计划的目标是通过向住院医生提供正式的研究方法指导、试点资金和参与指导研究项目的机会来促进临床研究事业。K24奖项的延续对保护鲍尔博士的时间至关重要，使他能够继续为与生物标记物和骨骼脆性相关的以患者为导向的研究做出重大贡献，并扩大他成功的指导计划。

DESCRIPTION (provided by applicant): Osteoporosis is a significant concern for both older men and women. Recent studies suggest skeletal biomarkers might provide important information about the biologic causes of osteoporosis and may be useful to predict fracture alone or when combined with other risk factors. To extend his ongoing NIH-funded work on biomarkers and skeletal fragility, Dr. Douglas Bauer, Professor of Medicine, Epidemiology & Biostatistics at the University of California, San Francisco, is requesting a renewal of his K24 Midcareer Investigator Award in Patient-Oriented Research with the scientific goals of developing new and clinically useful proteomic biomarkers using data from a well characterized longitudinal cohort of older men (MrOS). Taking advantage of ongoing assessments for fracture and recent funding for proteomic measurements in serum collected at baseline, this study will explore the prospective relationship between proteomic profile and incident vertebral fracture in 3000 MrOS participants. Using these and other data from multiple large studies available through his longstanding affiliation with the San Francisco Coordinating Center, Dr. Bauer will continue to mentor young investigators who are interested in clinical research, particularly residents. With the initial K24 award Dr. Bauer mentored residents and fellows who are now pursuing additional research training and academic careers. In conjunction with the UCSF Clinical and Translational Science Institute, during the initial K24 award he also developed and directed a new comprehensive Resident Research Program. The goal of this novel program is to promote clinical research careers by providing residents with formal instruction in research methods, pilot funding and opportunities to participate in mentored research projects. The continuation of this K24 award is critical to protect Dr. Bauer's time and allow him to continue to make significant contributions towards patient-oriented research related to biomarkers and skeletal fragility and to expand his successful mentoring program.