Sex differences in carpal tunnel syndrome using person reported outcomes and

腕管综合征（CTS）是最常见的周围神经卡压障碍 （手腕处的正中神经），也是最普遍的现代上肢肌肉骨骼疾病之一。 紊乱尽管它的流行，确切的病因和病理生理基础的CTS是不清楚的，在这一点上， 这个项目将解决这些知识的差距，并有助于进一步了解我们的 疾病机制，从而提高整体临床护理CTS患者提供预防 措施或替代治疗策略。该研究对于CTS领域来说是新颖的，并且代表了 最大的自然史研究，结合了最先进的高分辨率超声（HRUS）， 电诊断/肌电图（EDX）方法。我们将跟随一群女性和男性， 采用前瞻性自然史研究设计的特发性CTS，采用6周“标准治疗” 保守性腕关节夹板治疗，并随访12个月。目标1： 确定并比较患有和不患有特发性CTS的女性的基线HRUS特征 （根据年龄和BMI调整），以及患有和不患有特发性CTS的男性（根据年龄和BMI调整）。目标二： 确定并按性别比较新HRUS特征和患者报告结局的能力 CTS中检测男性治疗前后治疗效果变化的措施， 6周标准夜间中性腕关节夹板治疗后的女性;并评估与 CTS严重程度和进展的其他传统测量（如通过手图、敏感性 测试、挑衅性机动和EDX参数）。目的3：确定和比较患者 特征（年龄、性别、BMI、手腕人体测量学、工作相关风险因素）、健康相关生活质量 CTS严重程度的临床测量（物理测量、电诊断和超声检查） 参数）与特发性CTS的短期和长期结局相关。 相关性（参见说明）： 标准化高分辨率超声方法学的建立和试验方法的确定 腕管综合征的诊断和监测能力将产生重要影响，不仅在 腕管综合征患者的健康护理，但也将有深远的影响，减少 社会的医疗保健成本和经济生产力的提高。

Carpal tunnel syndrome (CTS) is the most frequently occurring peripheral nerve entrapment disorder (median nerve at the wrist) and is also one of the most prevalent modern-age upper limb musculoskeletal disorders. Despite its prevalence, the exact etiology and pathophysiology underlying CTS is unclear at this time.This project will address these gaps in knowledge and contribute to furthering our understanding of disease mechanism, and thereby improve the overall clinical care of patients with CTS by offering preventive measures or alternative therapeutic strategies. The proposed study is novel for the CTS field, and represents the largest natural history study incorporating the state-of-the-art high-resolution ultrasound (HRUS) and electrodiagnosis/electromyography (EDX) methodologies. We will follow a cohort of females and males with idiopathic CTS using a prospective natural history study design with 6 weeks of 'standard-of-care' conservative wrist splint treatment, and follow up for 12 months with the following aims. Aim 1: To determine and compare the baseline HRUS characteristics in females with and without idiopathic CTS (adjusted for age and BMI), and in males with and without idiopathic CTS (adjusted for age and BMI). Aim 2: To determine and compare by sex the ability of novel HRUS characteristics and patient-reported outcome measures in CTS to detect treatment effect changes between the pre- and post-treatment in men and women after 6 weeks of standard nocturnal neutral wrist splint treatment; and evaluate for correlation with other traditional measures of CTS severity and progression (as measured by hand diagram, sensibility testing, provocative maneuvers, and EDX parameters). Aim 3: To determine and compare the patient characteristics (age, sex, BMI, wrist anthropometrics, job-related risk factors), health-related quality of life measures, and clinical measures for CTS severity (physical measures, electrodiagnostic and sonographic parameters) in relation to short- and long-term outcomes in idiopathic CTS. RELEVANCE (See instructions): Establishment of standardized high-resolution ultrasound methodologies and determination of test capabilities in the diagnosis and monitoring of carpal tunnel syndrome will have important impact not only in health care of individuals with carpal tunnel syndrome but will also have far-reaching implications of reduced healthcare cost to society and increased economic productivity.