Interactions between the serotonin transporter and sympathetic nervous activation in patients with major depressive disorder - Understanding the link between the brain and the heart

有证据表明，患有严重抑郁障碍(MDD)的患者患心脏病的风险增加。虽然机制尚不清楚，但我们先前已经证明，MDD患者的心脏交感神经活动遵循双峰分布，某些患者的值非常高。在这个项目中，我们将确定交感神经激活在MDD患者中的生理后果。

There is evidence that patients with major depressive disorder (MDD) are at increased risk of developing heart disease. While the mechanisms responsible remain unknown we have previously demonstrated that cardiac sympathetic nervous activity in patients with MDD follows a bimodal distribution, with values in some patients being extraordinarily high. In this project we will determine the physiological consequences of sympathetic activation in patients with MDD.