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中文摘要
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发育研究计划(DRP)是大脑中Duke孢子的重要组成部分 癌症。该计划的目标是确定和支持有前景的试点研究项目, 与脑瘤相关的研究潜力来自其他领域经验丰富的研究人员。项目将是 鼓励广泛协作并测试新的范例,以进一步扩大大脑的范围 肿瘤的诊断、预防和治疗。DRP将专门针对那些具有较强 成为成功和独立的研究项目或具有很高开发潜力的可能性 变成完整的孢子项目,以取代孢子内进展不令人满意的项目。这个 DRP的具体目标是: 1)确定并支持有经验的研究人员的有价值的翻译研究项目 其他极有可能影响诊断、治疗或预防的领域 脑肿瘤; 2)吸引目前不从事脑瘤研究的新的、杰出的和有经验的研究人员 从事脑瘤研究;以及 3)持续评价受资助项目的进展情况,并促进其演变为 全孢子项目或独立资助项目。 《脑癌DRP》中提出的杜克孢子建立在前杜克非常成功的DRP的基础上 脑孢子,导致了几个由同行审查的资助项目。在这个新的应用程序中,我们提供了一个 强大的项目识别、选择和评估计划,将确保我们支持令人振奋的新项目 项目,申请表中列出的潜在项目的例子就是明证。我们还希望吸引 杰出的新人在脑瘤领域工作,促进新的富有成效的合作 杜克大学脑瘤研究人员和杜克大学其他部门的研究人员之间的合作 机构和行业。我们还制定了一个全面的计划,包括与公爵的互动 医学院多样性办公室和杜克大学生物医学研究生多样性办公室,以及, 与选定的当地机构建立伙伴关系,如以黑人为主的北卡罗来纳州中央大学,以 增加有研究兴趣的杰出少数群体和女性调查员参与DRP 与脑瘤有关。
英文摘要
The Developmental Research Program (DRP) is a critical component of the Duke SPORE in Brain Cancer. The goal of the Program is to identify and support promising pilot research projects with translational research potential relevant to brain tumors from experienced investigators in other fields. Projects will be encouraged to be broadly collaborative and to test novel paradigms that will further expand the scope of brain tumor diagnosis, prevention, and management. The DRP will specifically target projects that have a strong likelihood of becoming successful and independent research projects or have a high potential of developing into full SPORE projects to replace projects within the SPORE that are not progressing satisfactorily. The Specific Aims of the DRP are to: 1) Identify and support meritorious translational research projects from experienced investigators in other fields that have a high probability of impacting the diagnosis, treatment or prevention of brain tumors; 2) Attract new, outstanding, and experienced investigators currently not working on brain tumors to pursue brain tumor research; and 3) Provide continuing evaluation of progress on funded projects and facilitate their evolution into full SPORE projects or independently funded projects. The proposed Duke SPORE in Brain Cancer DRP builds upon the highly successful DRP of the previous Duke Brain SPORE that had resulted in several peer-reviewed funded projects. In this new application, we present a strong plan for project identification, selection, and evaluation that will ensure that we support exciting new projects, as evidenced by the examples of potential projects listed in the application. We also expect to attract outstanding new individuals to work in the brain tumor field and to facilitate new productive collaborations between Duke brain tumor investigators and investigators in other components of Duke University, other institutions, and industry. We have also put in place a comprehensive plan, including interactions with the Duke School of Medicine Office of Diversity and the Duke Office of Biomedical Graduate Diversity, as well as, partnerships with select local institutions, such as the predominantly black North Carolina Central University, to increase the participation, in the DRP, of outstanding minority and women investigators with research interests relevant to brain tumors.
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Project 3 Supplement - A Novel Cellular Tumor Vaccine Strategy for Mutant IDH1 glioma
  • 批准号:
    10184915
  • 项目类别:
  • 资助金额:
    $16.09万
  • 财政年份:
    2014
  • 负责人:
    FRANCIS ALI-OSMAN
  • 依托单位:
Duke SPORE in Brain Cancer
  • 批准号:
    9333295
  • 项目类别:
  • 资助金额:
    $229.8万
  • 财政年份:
    2014
  • 负责人:
    FRANCIS ALI-OSMAN
  • 依托单位:
Duke SPORE in Brain Cancer
  • 批准号:
    8805232
  • 项目类别:
  • 资助金额:
    $216.2万
  • 财政年份:
    2014
  • 负责人:
    FRANCIS ALI-OSMAN
  • 依托单位:
Duke SPORE in Brain Cancer
  • 批准号:
    10705225
  • 项目类别:
  • 资助金额:
    $208.79万
  • 财政年份:
    2014
  • 负责人:
    FRANCIS ALI-OSMAN
  • 依托单位:
海外基金