Resolution of Neuroinflammation and Persistent Pain by Complementary Approaches

该计划项目的目标是建立一个NCCIH卓越中心，以研究神经炎性 多种互补和综合保健(CIH)办法的基础机制，包括 电针和天然产物二十二碳六烯酸。关于整个P01的首要假设 不同的CIH方法可能会修改不同的炎症和神经炎性特征，以实现 它们在疼痛管理方面的治疗潜力。这一假设将在4个项目中用4只动物进行验证 与不同类型的临床疼痛情况相关的模型，结合性别和压力。作为对.的回应 美国阿片类药物危机愈演愈烈，PPG将进行尖端基础科学研究，为 在该中心进行未来的临床试验，以快速转换已确定的补充方法，这些方法可以 有效调节神经炎症。

The goal of this program project is to establish a NCCIH Center of Excellence is to investigate neuroinflammatory mechanisms underlying multiple complementary and integrative health (CIH) approaches, including electroacupuncture and natural product docosahexaenoic acids. The overarching hypothesis for the entire P01 is that different CIH approaches may modify distinct inflammatory and neuroinflammatory profiles to achieve their therapeutic potentials in pain management. This hypothesis will be tested in 4 projects using four animal models relevant to different types of clinical pain conditions, in combination with sex and stress. In response to rising opioid crisis in the US, this PPG will conduct cutting-edge basic science research and pave the road for future clinical trial at the center for rapid translation of the identified complementary approaches that can effectively modulate neuroinflammation.