House Research Institute Core Center

描述（由申请人提供）：众议院研究所（HRI）包含广泛的耳和前庭研究，从基础细胞和遗传机制的研究到临床试验。HRI在听力基础科学和临床创新方面取得了许多进展。HRI成功的一个秘诀是，所有的研究和临床项目都得到了共享核心设施的支持，这些设施提供了工程、成像、临床trias管理、统计和动物管理方面的专业知识。与大学环境不同，HRI在一栋建筑物内拥有所有这些研究广度。例如，允许研究人员精确控制电刺激的相同植入物接口也可以用于在更大的临床人群中测试新的刺激策略。药物发现和开发发生在相同的实验室，然后设计这些药物的临床试验。技术基础设施核心提供跨研究领域和项目的专业知识，增强HRI的研究能力。从基础研究到应用研究的纵向一体化也促进了这方面的合作，特别是当它们使用核心基础设施开发的共同设备和软件时。本申请要求继续为HRI工程核心中心提供资金。该P-30续签补助金的目的是扩大和维持众议院研究所（HRI）核心中心的作用，为超过16名独立调查员（其中9名是合格的核心调查员）及其合作者提供广泛的技术和其他关键核心服务。HRI核心中心的服务将继续保持HRI最先进的技术能力和专业知识，促进HRI科学家之间的互动，并因此帮助制定和开发新的研究方向。

DESCRIPTION (provided by applicant): The House Research Institute (HRI) contains a wide range of ear and vestibular research, from research on basic cellular and genetic mechanisms to clinical trials. HRI has pioneered many advances in the basic science of hearing as well as clinical innovation. One secret to HRI's success is that all research and clinical programs have the support of shared core facilities that provide expertise in engineering, imaging, clinical trias management, statistics, and animal management. Unlike a university environment, HRI has all this research breadth within a single building. For example, the same implant interface that allows researchers precision control of electric stimulation can also be used to test new stimulation strategies in a larger clinical population. Drug discovery and development occurs in the same laboratories that then design the clinical trials for those drugs. Technical infrastructur cores provide expertise across research areas and projects, enhancing HRI research capabilities. The vertical integration of research, from basic to applied, also promotes collaboration across this dimension, especially when they use common equipment and software developed by the core infrastructure. The present application requests continued funding for the HRI Core Center for Engineering. The purpose of this P-30 renewal grant is to expand and maintain the House Research Institute (HRI) Core Center's role in supporting a wide range of technical and other critical core services to over 16 independent investigators (9 of which are Qualifying Core Investigators) and their collaborators. The services of the HRI Core Center will continue to maintain state-of-the-art technical competence and expertise at HRI, foster interaction among HRI scientists, and as such, will help set and develop new research directions.