Molecular Design of Advanced Biomaterials

描述(由申请人提供)：我们建议在科布雷第一阶段和第二阶段奖项的成功基础上，建立四个研究核心，为采取的基础设施提供基础设施 我们的中心更上一层楼。此外，Cobre III将为试点研究项目提供一种机制，以继续发展生物材料研究领域充满活力的研究团队。在分子水平上设计的新型生物材料可能会出现重大的生物医学疗法，以提供对机械和生物特性的定制控制。这种生物材料的实现需要有机化学、分子设计、生物化学、生物学、生物物理化学和材料工程等不同研究群体之间的协同作用。一批优秀的初级、中期和高级研究人员在第一阶段和第二阶段Cobre奖期间建立了跨校园多个单位的合作关系，并将在Cobre III中扩展。我们为Cobre III提出了四个具体目标：i)开发最先进的自我维持的研究仪器核心(核磁 其中包括：i)建立科布雷研究中心；ii)建立一个试点研究分项目计划，使科布雷计划能够开创新的研究方向，将新的初级研究人员引入科布雷计划，并促进新的合作；iii)建立科布雷资助的研讨会和会议(年度研究和协调务虚会，以及共同赞助生物材料方面的讲座)；以及iv)建立科布雷教员辅导计划。这些目标将进一步发展一支由NIH ROI资助的研究人员队伍，他们的尖端生物材料研究计划将继续为核心设施提供支持，这些设施对再生医学研究至关重要。 特拉华大学。

DESCRIPTION (provided by applicant): We propose to build on the success of COBRE phase I and phase II awards to establish four research cores that will provide the infrastructure to take our Center to the next level. In addition, COBRE III will provide a mechanism for pilot research projects to continue to develop vibrant teams of investigators in biomaterials research. Significant biomedical therapies are likely to emerge from novel biomaterials that are designed at the molecular level to offer customized control over mechanical and biological properties. The realization of such biomaterials requires synergy between diverse research communities of organic chemistry, molecular design, biochemistry, biology, biophysical chemistry, and materials engineering. Collaborations between an outstanding group of junior, mid-career and senior investigators spanning multiple units across campus were established during phase I and phase II COBRE awards and will be extended in COBRE III. We propose four specific aims for COBRE III: i) to develop state-of-the-art self-sustained research instrumentation cores (Nuclear Magnetic Resonance; Mass Spectrometry and Surface Characterization; Microscopy and Mechanical Testing; and Computational Modeling) that will be integrated into campus-wide infrastructure; ii) to establish a pilot research subproject program that will enable the PIs to initiate new research directions, to bring new junior investigators to the COBRE program, and to promote new collaborations; iii) to establish COBRE-supported symposia and meetings (an annual research and coordination retreat, and co-sponsored lectures in biomaterials); and iv) to establish a COBRE faculty mentoring program. These aims will further the development of a cadre of NIH ROI funded investigators whose cutting-edge biomaterial research programs will provide continuing support for the core facilities that are a crucial for regenerative medicine research at the University of Delaware.