Pharmaceutical Aspects of Biotechnology

描述（由申请人提供）：该计划的目标是培养制药科学家处理生物技术研究产生的产品开发（即治疗药物和疫苗）。由于开发生物技术衍生药物的难度和复杂性，有必要培养一种新的“品种”制药科学家，他们能够通过整合数学，物理，生物学，分子生物学和化学来解决设计未来治疗剂的难题，以满足生物，化学和制药科学进步的跨学科方法的需求。这种新型科学家也可以在学术机构中就业，以扩大对未来制药生物技术科学家的教育培训。这个培训项目已经存在了26年，有37名教师导师和8名学生将参加培训项目。该培训计划有三个主要研究领域：(1)传统“制药”领域，包括形成、分析和递送；(2)蛋白质结构和生物信息学领域；(3)疫苗稳定和配方领域。37位教师导师分别来自不同院系（如化学、药物化学、机械工程、分子生物科学和药物化学等）和中心（亚当斯生物分析化学研究所、生物工程和生物信息学中心）。指导委员会监督生物技术培训计划的所有方面；Drs。Siahaan和Volkin分别担任该项目的PI和Co-PI。这些学生将从参与部门的教师导师提名的申请者中选出。督导委员会每年会从获提名的学生中选出学员。学员必须参加培训计划的必修课和选修课，包括负责任的研究行为课程。学生还需要进行3-6个月的行业实习。学生的进步将在季度会议和每年的KU静修中进行监督。学员们组织了与科罗拉多大学生物技术培训项目联合举办的中大-堪萨斯联合研讨会。受训者将得到培训计划最多两年的支持。在工业界和学术界工作了5年的该项目校友将被邀请在一年一度的堪萨斯大学静修会上展示他们的研究成果，并对培训项目提供反馈。

DESCRIPTION (provided by applicant): The objective of this program is to train pharmaceutical scientists to handle the development of products arising from biotechnology research (i.e., therapeutic drugs and vaccines). Due to the difficulty and complex nature of developing biotechnology-derived drugs, it is necessary to train a new "breed" of pharmaceutical scientists who can respond to the need for interdisciplinary approaches for the advancement of biological, chemical, and pharmaceutical sciences by integrating mathematics, physics, biology, molecular biology, and chemistry to solve difficult problems in designing therapeutic agents of the future. This new type of scientist could also be employed in academic institutions to expand the educational training of future pharmaceutical biotechnology scientists. This training program has been in existence for 26 years with 37 faculty mentors and eight students will be in the training program. There are three major areas of research in this training program: (1) the traditional "pharmaceutics" area that includes formation, analysis, and delivery, (2) the protein structure and bioinformatics area, and (3) the vaccine stabilization and formulation area. The 37 faculty mentors are from various departments (e.g., Chemistry, Medicinal Chemistry, Mechanical Engineering, Molecular Biosciences, and Pharmaceutical Chemistry, etc.) and Centers (Adams Institute for Bioanalytical Chemistry, Bioengineering and Bioinformatics Centers). The Steering Committee oversees all aspects of the Biotechnology Training Program; Drs. Siahaan and Volkin serve as the PI and Co-PI of the program, respectively. The students will be selected from a pool of applicants that are nominated by the faculty mentors from the participating departments. The Steering Committee will select the trainees from the nominated students each year. The trainees have to take required and elective courses for the training program including a course on responsible conduct in research. The students are also required to do 3-6 months industrial internship. The students' progress will be monitored in quarterly meetings and annual KU retreat. The trainees organize the Joint CU-KU Symposia, which is a joint symposium with the Biotechnology Training Program at the University of Colorado. The trainees will be supported by the training program for a maximum of two years. The alumni of this program who have been working for five years in industry and academia will be invited to present their research at the yearly KU retreat as well as to provide feedback on the training program.