UCLA Center for AIDS Research (CFAR)

本申请是加州大学洛杉矶分校（UCLA）对艾滋病研究中心（CFAR）资助的一次更新。这笔赠款将资助UCLA艾滋病研究所内UCLA CFAR开展的活动和项目。加州大学洛杉矶分校CFAR成立于1988年，艾滋病研究所成立于1992年，负责协调大学及其附属教学医院的所有艾滋病研究，临床和教育活动。艾滋病研究所和CFAR的整体组织结构在2005年进行了重组，以更有效地管理艾滋病研究活动，采用自下而上的治理方法，允许所有教职员工参与我们所有的计划。此更新应用程序包括CFAR核心服务和活动，旨在通过基础，临床和行为科学提高对艾滋病毒/艾滋病的认识。加州大学洛杉矶分校CFAR的总体使命是在不同学科之间创造协同效应，从而在理解、预防和治疗艾滋病毒感染方面取得重大突破，特别强调高价值的跨学科合作。加州大学洛杉矶分校的CFAR由200多名研究人员组成，他们负责的研究项目几乎涵盖了艾滋病毒/艾滋病生物学、临床研究和行为科学的所有方面。加州大学洛杉矶分校在艾滋病研究、教育和教学以及临床项目方面一直被列为顶尖机构。CFAR的作用是通过支持科学和行政核心设施，以及为非常有价值的合作和跨学科研究项目提供种子补助金，促进大学内外的合作和建立联系。CFAR计划继续支持先前CFAR赠款资助的9个核心：行政核心，发展核心，病毒学/BSL 3组织培养核心，细胞计数核心，人源化小鼠核心，基因和细胞治疗核心，粘液免疫学核心，临床研究促进核心和生物统计学核心。根据不断变化的流行病学，需求评估，战略规划和修订的短期和长期目标，我们取消了一个核心，并通过我们的临床研究促进核心开发了HIV+和HIV-受试者登记。纳入这一资源将非常有利于临床，行为和基础科学研究。

This application constitutes a renewal on the part of the University of California Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage the AIDS research activities with a bottom-up approach to governance, allowing participation by all faculty in all of our programs. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross disciplinary collaborations. The UCLA CFAR consists of more than 200 investigators who are responsible for research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative and interdisciplinary research projects. The action plan for the first year of requested support is summarized as follows: The CFAR plans to continue supporting nine of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Humanized Mouse Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, a Clinical Research Facilitation Core and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short-and long-term goals, one core was eliminated and we developed an HIV+ and HIV- subject registry through our Clinical Research Facilitation Core. Inclusion of this resource will be highly beneficial to clinical, behavioral and basic science studies.