Steroid Hormone Action In Female Reproduction

本项目聚焦于平滑肌瘤（肌瘤），并探讨其发病机制、诊断和/或潜在治疗的相关因素。正在进行的工作旨在评估黄体酮反应调节剂CDB2914作为子宫肌瘤治疗的效用。我们之前研究了单次剂量的药物对女性月经周期的影响，并表明100或200毫克的剂量分别在卵泡期和黄体期延缓卵泡发生和月经沉淀。

This project focuses on leiomyomata (fibroids) and examines factors related to their pathogenesis, diagnosis and/or potential treatment. Ongoing work seeks to evaluate the utility of the progesterone response modulator CDB2914 as a treatment of fibroids. We previously investigated the effect of single doses of the agent on the menstrual cycle in women, and showed that doses of 100 or 200 mg retard folliculogenesis and precipitate menses, in the follicular and luteal phase respectively. Two randomized double-blind placebo-controlled clinical trials from our group showed reduction in fibroid size in women receiving CDB 2914 at a daily dose of 10 or 20 mg for three months, as compared to women receiving placebo. One of these studies showed continued efficacy during a second three-month study. We also are using gene arrays to evaluate the pathophysiology of leiomyomata.