Molecular Basis of Host Parasite Interaction

描述(申请人提供)：由微生物病原体引起的全球疾病负担仍然是国际生物医学界面临的最大挑战之一。艾滋病、疟疾和结核病是全球主要的死亡原因之一。此外，这些微生物中的许多对多种抗菌疗法具有耐药性，这突显了对新疗法和疫苗的需要。我们的培训计划为博士后和博士后研究员提供的关于病原体、本土微生物区系和宿主免疫系统之间复杂相互作用的更多知识将导致治疗、治愈和预防各种疾病的新方法。斯坦福大学微生物学和免疫学系在宿主-病原体相互作用方面开展了一项世界级的培训计划，该计划基于四大支柱：有才华的学生/博士后、敬业的教师、严格而彻底的培训以及敬业的大学员工和基础设施。该项目是多学科的， 具有巨大的广度和深度。我们研究宿主-寄生虫相互作用的许多方面-微生物(病毒、细菌或原生动物)、宿主和一起作为一个系统。一些研究小组研究了宿主与本地微生物区系的相互作用，以及这种微生物区系成员之间的相互作用。微生物群的成员被研究为它们作为共生体和病原体的能力。其他人则研究宿主病原体相互作用的分子生物学。我们还开发了监测这些相互作用的技术，如Cytoff、Spade和生物发光成像和培养技术。我们使用了从苍蝇到老鼠的整个动物模型，我们最先进的人类免疫监测中心现在允许我们扩大我们在人类生物学方面的工作。我们的学生和博士后是成功的，他们发表了影响很大的论文，并在科学的各个方面找到了很好的位置，从研究到教学，到政策和咨询。我们每年平均招收6名博士后和大约30名博士后。我们使用培训补助金来支持研究生的头三年教育，以及一年(或在特殊情况下，两年)对选定的博士后的资助。我们请求继续我们目前的供资水平，即8个博士前培训时段和4个博士后培训时段。这笔赠款在过去的24年里一直很活跃，我们要求再提供5年的资金。

DESCRIPTION (provided by applicant): The global burden of disease caused by microbial pathogens remains one of the largest challenges facing the international biomedical community. Among the leading causes of mortality worldwide are the causative agents of AIDS, Malaria and Tuberculosis. Furthermore, many of these microbes are resistant to multiple antimicrobial therapies, highlighting the need for new therapies and vaccines. The increased knowledge of the complex interactions between the pathogen, indigenous microbiota and host immune system that our Training Program offers to pre-and postdoctoral fellows will lead to new ways to treat, cure and prevent various diseases. The Department of Microbiology and Immunology at Stanford runs a world class training program in Host- Pathogen interactions and the program stands on four pillars: talented students/postdocs, committed faculty, rigorous and thorough training, and a dedicated university staff and infrastructure. The program is multidisciplinary and has tremendous breadth and depth. We study many aspects of host-parasite interactions- the microbe (viral, bacterial or protozoal), the host and together as a system. Some groups study the host's interaction with native microbiota and between members of this microbiota. The members of the microbiota are studied both for their ability to act as symbionts and pathobionts. Others study the molecular biology of host pathogen interactions. We also develop techniques for monitoring these interactions, like Cytoff, Spade and bioluminescent imaging and culturing techniques. Whole animal models from flies to mice are used and our state of the art Human Immune Monitoring Center now allows us to expand our work in human biology. Our students and postdocs are successful, publishing high impact papers and finding terrific positions in all aspects of science, from research to teaching to policy and consulting. We have been recruiting an average of 6 predoctoral students and approximately 30 postdocs to the program per year. We use the training grant to support the first three years of our graduate students' education and one (or in exceptional cases, two years) of funding for select postdocs. We are requesting to continue our present level of funding of 8 pre-doctoral training slots and 4 postdoctoral traine slots. The grant has been active for the past 24 years and we are requesting another 5 years of funding.