Role of CDC14B in mouse oocyte maturation

单倍体配子是有性生殖所必需的，是由二倍体前体细胞通过 减数分裂在雌性中，卵母细胞经历2个主要的减数分裂特异性细胞周期转换， 不太了解。第一个转变是减数分裂恢复，此时卵母细胞退出延长的前期停滞 并进入第一减数分裂M期（Ml），第二减数分裂M期是Ml和Mil之间的过渡期， 同源染色体分离，没有一轮DNA合成发生。 该项目始于PI（Karen Schindler）在大学担任博士后研究员时 宾夕法尼亚州，并促进了过渡到一个独立的研究生涯。这些研究调查 导致雌卵非整倍性的分子机制将形成一个独立的 新泽西的州立大学罗格斯遗传学系的一项研究计划， PI将于2012年1月担任终身教职。罗格斯大学的研究环境 生殖生物学和非整倍体是杰出的，完成研究所需的所有资源， 该机构致力于促进新调查员的发展。因此，PI将 有能力竞争额外的资金，并有一个成功的独立研究生涯。

Haploid gametes, that are essential for sexual reproduction, are generated fronn diploid precursor cells via meiosis. In females, oocytes undergo 2 major meiosis-specific, cell-cycle transitions wtiose regulation are poorly understood. Thie first transition is meiotic resumption where oocytes exit a prolonged prophase arrest and enter the first meiotic M phase (Ml), and the second is the transition between Ml and Mil where homologous chromosomes separate and no round of DNA synthesis occurs. This project began while the PI (Karen Schindler) was a postdoctoral fellow at the University of Pennsylvania and has facilitated transition to an independent research career. These studies investigating the molecular mechanisms that lead to aneuploidy in female eggs will form the basis of an independent research program in the Department of Genetics at Rutgers, The State University of New Jersey where the PI will assume a tenure-track faculty position in January 2012. The environment at Rutgers for research in reproductive biology and aneuploidy is outstanding, all resources required to complete the studies are available, and the institution is committed to promoting development of new investigators. Thus, the PI will be well-positioned to compete for additional funding and to have a successful independent research career.