Prevention of PTSD III: Neurocognitive Training of Emotional Regulation

描述（由申请人提供）：拟议的工作将评估执行功能和情绪调节的神经认知再训练的能力，以减少创伤暴露后的神经认知功能障碍，从而预防创伤后应激障碍。这项工作的科学原理是假设受损的情绪调节干扰了对创伤事件的早期反应的预期恢复，导致慢性疾病。在初始阶段，我们将招募20名最近创伤的参与者，他们是在创伤幸存者中进入综合医院急诊室的，并测试计划的干预措施的接受程度和正确的“剂量”。在第二阶段，我们将招募80名最近的幸存者参加新干预措施的随机对照研究。干预将包括基于网络的神经行为训练干预，灌输对积极刺激的情绪偏见，改善情绪识别和标签，减少对情绪分散的抵抗力，并增强执行功能。对照组的参与者将完成基于网络的视频游戏，这些游戏没有情绪调节的好处。结果测量将包括神经认知功能和PTSD症状的改善。

DESCRIPTION (provided by applicant): The proposed work will evaluate the ability of neurocognitive retraining of executive functions and emotional regulation to reduce neurocognitive dysfunctions that follow trauma exposure and thereby prevent PTSD. The scientific rationale for this work is the hypothesis that impaired emotional regulation interferes with the expected recovery from the early responses to traumatic events, leading into a chronic disorder. In an initial phase we will recruit 20 recently traumatized participants among trauma survivors admitted to a general hospital emergency room and test the planned intervention's acceptance and right 'dosing'. In the second phase we will enroll 80 recent survivors into a randomized controlled study of the new intervention. The intervention will consist of web-based neurobehavioral training interventions that instill an emotional bias toward positive stimuli, improve emotion recognition and labeling, reduce resistance to emotional distraction, and enhance executive functioning. Control participants will complete web-based video games that do not have emotion-regulatory benefits. Outcome measures will include improvement in neurocognitive functioning and in PTSD symptoms.