2013 Fertilization and Activation of Development GRC/GRS

描述（由申请人提供）：此R13申请要求资金支持2013年施肥和激活发展戈登研究会议。2013年的会议将是第20次这样的会议，从1974年开始，从1977年开始每两年举行一次会议。这个戈登研究会议受精和激活发展解决无数的生物现象-生物化学，生物物理，分子，细胞和生理-影响两个配子的合并和一个新个体的发展开始。最近，2010年诺贝尔生理学或医学奖授予了罗伯特·G。爱德华兹为体外受精的发展强调了生物学和生物医学研究这一领域的重要性。受精和激活发展戈登研究会议是世界上唯一专门关注受精生物学的会议。2013年会议的科学计划将遵循非常成功的传统戈登研究会议格式，在上午和晚上举行会议，在下午和晚上会议后留出自由时间进行非正式和友好的互动。计划举行两次海报会议，科学会议将包括演讲者的演讲，主题包括影响配子的正常生殖过程的扰动（例如，年龄、环境暴露、辅助生殖技术）、生殖道环境对配子的影响、精子运动性和趋化性、精子进入卵子、卵子激活信号和事件以及介导成功的早期胚胎发生的过程。主题演讲将由Masaru Okabe博士发表，他是使用敲除技术分析受精表型的先驱。冈部博士将从历史和现在的角度介绍他在受精和配子生物学方面的工作。此外，他的演讲将讨论使用遗传模型来理解生殖过程。本次会议的总体目标是创建一个论坛，介绍和讨论前沿研究，营造一个充满活力和互动的氛围，以促进科学互动，并为年轻的研究人员以及来自传统上代表性不足的群体的参与者提供一个支持性的环境科学，包括妇女，代表性不足的少数民族/种族，和残疾人。除了我们通常的格式，今年我们自豪地与戈登研究研讨会受精和激活的发展。本次研讨会的目的是吸引年轻的研究人员在配子研究和受精领域。

DESCRIPTION (provided by applicant): This R13 application requests funds to support the 2013 Fertilization and Activation of Development Gordon Research Conference. The 2013 meeting will be the 20th such conference, having started 1974, and then meeting biennially since 1977. This Gordon Research Conference on Fertilization and Activation of Development addresses the myriad of biological phenomena - biochemical, biophysical, molecular, cellular, and physiological - that impact the merger of the two gametes and the initiation of the development of a new individual. The recent awarding of the 2010 Nobel Prize in Physiology or Medicine to Dr. Robert G. Edwards for the development of in vitro fertilization underscores the significance of this area of biology and biomedical research. The Fertilization and Activation of Development Gordon Research Conference is the only meeting worldwide focusing specifically on the biology of fertilization. The scientific program for the 2013 conference will follow the highly successful traditional Gordon Research Conference format with sessions held in the mornings and evenings, leaving free time in the afternoons and after the evening sessions for informal and friendly interactions. Two poster sessions are scheduled, and the scientific sessions will include talks by speakers on topics including perturbations to normal reproductive processes that affect the gametes (e.g., age, environmental exposures, assisted reproductive technologies), effects of the reproductive tract environment on the gametes, sperm motility and chemotaxis, sperm entry into the egg, egg activation signals and events, and processes mediating successful early embryogenesis. The keynote address will be presented by Masaru Okabe, PhD, who has pioneered the use of Knock Out technology to analyze fertilization phenotypes. Dr. Okabe will present his work in fertilization and gamete biology from both historical and present perspectives. In addition, his talk will discuss the use of genetic models t understand reproductive processes. The overarching goals for this conference are to create a forum for presentation and discussion of cutting-edge research, to foster a vibrant and interactive atmosphere to facilitate scientific interactions, and to provide a supportive environment for young investigators as well as participants from groups traditionally underrepresented in the sciences, including women, underrepresented ethnic/racial minorities, and people with disabilities. Added to our usual format, this year we proudly associated a Gordon Research Seminar on Fertilization and Activation of Development. This seminar has the objective to attract young investigators in the field of gamete research and fertilization.