EKU Lead Faculty Award

KBRIN-Centrated核心基金，在UofL也被称为UofL GG基因组学核心基金，自2008年以来一直作为INBRE-Cobre的合并业务运营，尽管自2001年以来某些单独的组成部分与INBRE或Cobre奖项分开提供。它的目标是向UofL研究人员以及KBRIN附属机构及其在肯塔基州的外展机构的研究人员提供最先进的基因组相关技术，包括微阵列和深度测序服务。它的服务集中在Affymetrix公司和安捷伦公司提供的最先进和全面的高密度寡核苷酸阵列技术平台，以及Jon Torrent PGM平台的下一代测序能力。这些平台允许对RNA或miRNA表达谱、剪接模式和变异、DNA突变和单核苷酸多态谱进行标准化分析。该设施确保所有研究人员，包括临床教员和基础科学小组，都能够采用这种最先进的技术，利用临床标本、动物模型或细胞培养材料来实现他们的研究目标。 自设立以来，该机制在人员、用户数量和实验平台的多样性、分配的空间、参加培训活动以及用于数据分析和挖掘的资源方面经历了快速增长。它一直是几个获得资助和/或目前悬而未决的个人和多名调查员中心和培训赠款申请的组成部分，这是其长寿和持续使用的最有力证据。该机构目前是Cobre 8P20GM103482-10分子靶标生物医学研究卓越中心(D.Miller，P.L.)、Cobre 8P20GM103453-10发育缺陷分子决定因素(R.Greene，P.L.)、NIGMS-KY-INBRE P20GM103436、KY-IDEA生物医学研究卓越网络奖(N.Cooper，P.L.)和培训拨款NIEHS T32 ES11564 UofL环境健康科学培训计划(D.Hein，P.L.)的重要组成部分。

The KBRIN-Centralized Core Facility, otherwise known at the Uofl, as the Uofl GG enomics Core Facility, has been operating as a merged INBRE-COBRE operation since 2008, although certain individual components were available separately from either the INBRE or COBRE awards since 2001. Its objectives are to provide state of the art genomic related technologies, including microarray and deep sequencing services to Uofl researchers as well as to investigators in the KBRIN-affiliated institutions and its outreach institutions across the Commonwealth of Kentucky. Its services are centered around the most advanced and comprehensive platforms of high-density oligonucleotide array technologies offered by Affymetrix, Inc. and Agilent, Inc, as well as the next generation sequencing capabilities of the Jon Torrent PGM platform. These platforms allow standardized analyses of RNA or miRNA expression profiles, splice patterns and variations, DNA mutations, and single nucleotide polymorphism profiles. The Facility ensures that all investigators, including clinical faculty and basic science groups, will be able to adopt such state-of-the-art technologies for their investigative goals using clinical specimen, or animal model or cell culture materials. Since its inception, the Facility has experienced a rapid growth in personnel, user numbers and diversity of experimental platforms, allocated space, attendance in training events, and resources for data analysis and mining. It has been an integral part of several funded and/or currently pending individual and multi-investigator Center and Training grant applications, the strongest case for its longevity and its continued utility. The Facility is currently a key component of COBRE 8P20GM103482-10 Center of Biomedical Research Excellence in Molecular Targets (D. Miller, P.l.), COBRE 8P20GM103453-10 Molecular Determinants of Developmental Defects (R. Greene, P.l.), NIGMS- KY-INBRE P20GM103436, KY-IDeA Networks of Biomedical Research Excellence award (N. Cooper, P.l.), and training grant NIEHS T32 ES11564 Uofl EElnvironmental Health Sciences Training Program (D. Hein, P.l.).