HVAC Improvements to Expand Research Capabilities at Colorado State University

项目摘要。该提案要求提供资金以购买更新后的空气处理机组(AHU) 大小约为13,500 cfm，以保持适当的温度和气压差 湿度、建筑自动化系统和排气扇取代了已有25年历史的 不再适用于科罗拉多州立大学的病理间隔室。《病理学》 目前，Vviilum拥有CSU的无特定病原体(SPF)猫群和少量 用于普恩病毒研究的老鼠笼子。这次升级为我们提供了极大的机会 在我们现有的动物设施内扩大我们的住宿能力和动物程序空间。 具体地说，Prion研究中心(PRC)的动物模型核心将整合到 病理性间隔膜和SPF猫巢。中国目前有动物被关押在 主要的动物收容设施，画家中心和病理室。超过了 在过去的三年里，中国的动物普查增加了4倍。这种快速增长已经 对画师中心的保存能力施加限制。然而，我们一直不愿 由于机械问题，将动物重新安置到病理间隔区的可用空间 在当前的空气处理机组上。在过去的两年里，已经有40多个服务电话 CSU设施管理解决诸如无法维护适当的 温度，无法保持适当的气流，以及无法保持适当的 SPF猫群生物安全的压差和Pron研究的生物遏制； 一项机械评估发现了许多问题。升级AHU将提供 稳定的环境控制，适当地安置更多的动物。巩固中华人民共和国 以病理间隔室为核心的动物模型将使其现有住房增加一倍以上 操纵空间。此外，它还将腾出画家中心的空间，这可能是 重新调整用途。目前在生物隔离之外只有两个程序室 调查员使用。通过将Prion用户转移到病理间隔室，我们可以致力于 为程序空间增加三个房间，并为以下对象创造额外的动物容纳空间 目前，新招聘的教职员工。这项提议将使53名首席调查员全部受益。 来自12个学术部门，目前有超过1.54亿美元的外部资助，包括 五名来自中国的教职员工(目前总资助额为1650万美元)。因为 大学的重点是传染病、癌症和其他生物医学研究倡议，这 该项目将加强一大批有益于动物和人类健康的研究。 与支持开发和维护最先进技术的良好记录保持一致 动物设施，研究副总裁，兽医学院院长 医学和生物医学科学，微生物学、免疫学系主任 和病理都热情地支持这一建议。一辆现代的阿胡也将 提供大量的能源节约。施工管理将考虑到 由LEED认可的设施专业项目经理指导的可持续概念。

Project Abstract. This proposal requests funds to acquire an updated air handling unit (AHU) sized approximately 13,500 cfm to maintain proper temperature and air pressure differentials with humidity, building automation system, and exhaust fans replacing a >25 year old unit that is no longer serviceable for the Pathology vivarium at Colorado State University. The Pathology viviarium currently houses CSU's specific pathogen free (SPF) cat colony and a modest number of mouse cages used in prion research. This upgrade provides us the opportunity to vastly expand our housing capabilities and animal procedure space within our existing animal facilities. Specifically, the animal model core of the Prion Research Center (PRC) will be consolidated into the Pathology vivarium along with the SPF cat colony. The PRC currently has animals held in both the main animal holding facility, the Painter Center, and the Pathology vivarium. Over the past three years, the PRC has seen a 4-fold increase in animal census. This rapid growth has put constraints on the Painter Center holding capabilities. However, we have been reluctant to relocate animals to the available space in the Pathology vivarium due to mechanical concerns over the current air handling unit. There have been over 40 service calls the past two years to CSU Facilities Management to address concerns such as inability to maintain the appropriate temperature, inability to maintain appropriate airflow, and inability to maintain appropriate pressure differentials for biosecurity of the SPF cat colony and biocontainment for prion studies; and a mechanical assessment identified numerous concerns. Upgrading the AHU would provide stable environmental controls to appropriately house additional animals. Consolidating the PRC animal model core to the Pathology vivarium will more than double their existing housing and manipulation space. Furthermore, it will vacate space in the Painter Center which could be repurposed. There are currently only two procedure rooms outside of biocontainment for investigator use. By moving the prion users to the Pathology vivarium we can dedicate an additional three rooms to procedure space, as well as create additional animal holding space for current, new faculty recruits. This proposal will benefit all of the 53 principal investigators from12 academic departments with over $154M in current extramural grant support, including five faculty members from the PRC ($16.5M in current total funding). Because of the University's focus on infectious disease, cancer, and other biomedical research initiatives, this project will enhance a large portfolio of studies conducted to benefit animal and human health. Consistent with a strong record of support for development and maintenance of state of the art animal facilities, the Vice President for Research, the Dean of the College of Veterinary Medicine and Biomedical Sciences, the Chair of the Department of Microbiology, Immunology and Pathology have all enthusiastically supported this proposal. A modern AHU will also provide substantial energy savings. Construction will be managed with consideration for sustainable concepts directed by a LEED Accredited Facilities Professional Project Manager.