FASEB SRC on Regulation and Function of Small GTPases

描述（由申请人提供）：本次会议将重点讨论“小型GTPases的调控和功能”。这是FASEB致力于该主题的一系列夏季研究会议中的第11次会议，在过去的20年里，它一直是该领域的“必去”会议。这次会议的持久承诺在于其继续关注复杂的信号转导途径，并使用最先进的技术和完善的模型系统来实现这一目标。小的gtp结合蛋白（如Ras、Rac、Rho、Cdc42、Rab、Rap、Rheb和Ral）调节多种细胞过程，包括增殖、迁移、发育、基因表达和代谢。此外，这些gtpase和下游效应通路的解除管制是许多人类疾病的基础，包括癌症、糖尿病、血管疾病和发育障碍。GTPase小超家族的创始成员Ras是人类癌症中最常见的突变致癌基因，与它的效应物一起，是药物发现的主要目标。在过去的十年中，许多其他家族成员已被证明在癌症和转移中起重要作用（RhoA, Rac1, Rab5, Rheb, RalA）。会议的主要目的是促进跨越基本生化机制、细胞和组织生物学以及转化研究的不同研究人员之间的思想交流。因为Ras， Rac, Rab, Rho， Rheb和Ral在癌症和转移中起着特别重要的作用，所以这次会议将会有一个强烈的癌症主题。然而，我们也将强调一些生物学领域（代谢、神经生物学、发育生物学）的进展，以确保我们正在利用和学习其他重要相关领域的发现。为了加强思想交流，会议将围绕生物学主题进行安排，但包括各种方法和模型系统。拥有广泛和互补专业知识的个人并置将确保出现新的想法并建立未来的合作。会议将于2012年6月2日至7日在科罗拉多州的蒸汽船泉举行，这是促进非正式讨论和支持协作环境的理想场所。来自美国、欧洲、新加坡、日本的35位受邀演讲嘉宾（均已确定）。我们将特别关注下一代研究人员的参与，16场讲座将由学生、博士后或刚刚开始独立职业生涯的研究人员进行。

DESCRIPTION (provided by applicant): This conference will focus on the 'Regulation and Function of Small GTPases'. It is the eleventh in a series of FASEB summer research conferences devoted to this topic and it has been the "must go to" meeting in the field for the last 20 years. The enduring commitment to this meeting lies in its continued focus on unravelling complex signal transduction pathways and using state-of-the art technology and refined model systems to do so. Small GTP-binding proteins (e.g. Ras, Rac, Rho, Cdc42, Rab, Rap, Rheb and Ral) regulate diverse cellular processes including proliferation, migration, development, gene expression, and metabolism. Moreover, the deregulation of these GTPases and downstream effector pathways underlies many human diseases, including cancer, diabetes, vascular disease and developmental disorders. The founding member of the small GTPase superfamily, Ras, is the most commonly mutated oncogene in human cancers and, together with its effectors, is a major target for drug discovery. Over the last decade, many other family members have been shown to be fundamental in cancer and metastasis (RhoA, Rac1, Rab5, Rheb, RalA). The principal objective of the meeting is to stimulate cross-pollination of ideas among a diverse group of researchers that spans basic biochemical mechanisms, cell and tissue biology, and translational research. Because Ras, Rac, Rab, Rho, Rheb and Ral play a particularly important role in cancer and metastasis, there will be a strong cancer theme underlying this meeting. However, we will also highlight progress from a number of biological fields (metabolism, neurobiology, developmental biology) to ensure that we are leveraging and learning from discoveries made in other important related fields. To enhance the exchange of ideas, the sessions will be arranged around biological themes, but included varied approaches and model systems. The juxtaposition of individuals with wide-ranging and complementary expertise will ensure that new ideas emerge and future collaborations are established. The conference will be held June 2-7, 2012, in Steamboat Springs, Colorado, which is an ideal location for fostering informal discussions and supporting a collaborative environment. There are 35 invited speakers from the United States, Europe, Singapore and Japan (all of which are confirmed). We will particularly focus on engaging the next generation of researchers, and 16 talks will be given by students, post-docs or investigators just starting their independent career. Two discussion sessions will be held with the sole purpose of encouraging and advising the next generation on writing papers and getting grants. Poster sessions will further enhance the opportunity for the presentation and discussion of unpublished data. Specific attention has been paid to inclusion of women, and of young and minority investigators. While this meeting has always had an inclusive atmosphere we will also be offering 8 travel awards to minority and female applicants at various stages of their careers. This initiative will be detailed in the application. !