Translation of Quantitative Imaging in Osteoarthritis

描述(由申请人提供)：这项名为“骨关节炎定量成像的翻译”(TOQIO)的提案的总体目标是整合尖端的定量成像技术，将图像导出的指标与关节运动学、动力学、患者功能联系起来，并将发现的联系翻译到肌肉骨骼诊所，从而影响患者的管理和结果。为了实现这些目标，我们有一个联合团队，其中包括骨科外科医生、风湿病医生、成像科学家、生物工程师、物理治疗师、流行病学家和生物学家。这一团队建立在调查人员之间以转化性研究为重点的跨学科合作的坚实基础上，并得到了许多个人调查人员和方案赠款的支持，这些赠款在调查人员和机构之间建立了这些合作研究伙伴关系。TOQIO的主要目标是(I)提供基础结构并发展一个跨学科团队，以将有希望的新的成像方法和非侵入性生物标记物从原则证明转化为人类受试者的研究/试验，并最终转化为广泛可用的临床工具，直接影响患者对骨关节炎的护理和管理；(Ii)开发与功能相关的定量成像措施和生物力学之间的模型和关系，不仅用于监测和诊断骨关节炎，而且用于在临床试验中评估药物或手术治疗和受试者选择；以及(Iii)制定一项教育计划，让开发与骨关节炎研究相关的新技术的成像专家向基础和临床科学家传授如何使用这种方法来加强他们的研究，并将成像信息转化为骨关节炎的诊断和临床管理，以及利用TOQIO的中心主题开发新的试点和可行性项目。TOQIO由一个行政核心、四个研究项目和两个研究和科学核心组成：成像和数据分析以及人体性能和功能测试。此外，将有来自加州大学旧金山分校和加州大学戴维斯分校的参与者，以及一个出色的外部咨询委员会，其中包括一名社区成员的非专业意见。

DESCRIPTION (provided by applicant): The overall objective of this proposal entitled " Translation of Quantitative Imaging in Osteoarthritis" (TOQIO) is to integrate cutting edge quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. In order to accomplish these objectives we have a combined team that includes orthopedic surgeons, rheumatologists, imaging scientists, bioengineers, physical therapists, epidemiologists, and biologists. This team is built upon the strong foundation of interdisciplinary collaborations between the investigators, with a focus on translational research, and is supported by numerous individual investigator and programmatic grants that have established these collaborative research partnerships between the investigators and the institutions. The major goals of TOQIO are to (i) provide the infra-structure and develop an inter-disciplinary team to translate promising new imaging methodologies and non-invasive biomarkers from proof of principle to studies/trials in human subjects, and ultimately into widely available clinical tools that directly impact patient care and management of osteoarthritis; (ii) to develop models and relationships between the quantitative imaging measures and biomechanics that are relevant to function, not only for monitoring and diagnosing osteoarthritis, but also for assessing pharmaceutical or surgical therapies and subject selection in clinical trials; and (iii) to develop an educational program in which imaging specialists that develop the novel techniques relevant to osteoarthritis research teach basic and clinical scientists how to use such approaches in enhancing their research and translate the imaging information to the diagnosis and clinical management of osteoarthritis, as well as develop new pilot and feasibility projects utilizing the themes central to TOQIO. TOQIO consists of an administrative core, four research projects, and two research and scientific cores: Imaging and Data Analysis and Human performance and Functional Testing. In addition, there will be participants from UCSF and UC Davis and an excellent External Advisory Committee that includes lay input from a community member.