Neuropathology Core

神经病理学核心（核心D）作为每个项目的组成部分，提供组织病理学服务和神经病理学专业知识。核心PI（大卫R欣顿医学博士）和核心Colnvestigator（Roscoe Atkinson医学博士）都是委员会认证的神经病理学家，在小鼠中枢神经系统（CNS）组织评价方面具有丰富的经验。为每个项目提供的支持包括：1）参与动物实验的实验设计开发; 2）组织处理; 3）组织切片（冷冻切片和石蜡包埋切片）; 4）组织切片的组织化学和免疫组织化学染色; 5）组织切片的神经病理学解释（通过光学显微镜或共聚焦显微镜）; 6）通过数字显微镜记录病理学; 7）为手稿准备数字; 8）为每个项目存储和检索染色的载玻片。组织的专家准备和神经病理学评估可确保对CNS组织的病理学改变（包括炎症、脱髓鞘和病毒感染）进行高质量、无偏倚的评估。

The Neuropathology Core (Core D) functions as an integral component of each of the Projects providing histopathologic services and Neuropathologic expertise. The Core PI (David R Hinton MD) and Core Colnvestigator (Roscoe Atkinson MD) are both board certified Neuropathologists with extensive experience in the evaluation of murine central nervous system (CNS) tissues. Support provided to each of the projects includes: 1) participation in development of experimental design for animal experiments; 2) tissue processing; 3) tissue sectioning (frozen sections and paraffin-embedded sections); 4) histochemical and immunohistochemical staining of tissue sections; 5) neuropathologic interpretation of tissue sections (by light microscopy or confocal microscopy); 6) documentation ofthe pathology by digital microscopy; 7) preparation of figures for manuscripts; 8) storage and retrieval of stained slides for each of the projects. Expert preparation and neuropathologic evaluation of tissues ensures high quality, unbiased assessment of CNS tissues for pathologic alterations including inflammation, demyelination and viral infection.