In vivo irradiations with patients undergoing radiation therapy: dana farber canc

这一核心将在所有3个项目中发挥至关重要的作用， 这为开发技术和测试正在开发的仪器提供了独特的机会。在发展准确和有效的 对大量可能暴露于临床显著水平的电离辐射的人群进行分类的生物剂量学一直缺乏合适的样本和受试者来测试分析的有效性并促进技术的发展。合适的样品/受试者需要暴露于导致急性辐射综合征的剂量范围内的电离辐射（2 - 12戈伊）。为了开发方法而将人类个体暴露于这种剂量的辐射是完全不道德的，在动物模型中进行评价在这个开发阶段是不实用或不相关的。然而，我们可以利用接受这种辐射照射的患者作为骨髓抑制和免疫抑制治疗的一部分。DFCI是世界上为数不多的几个有大量患者接受TBI治疗的地方之一，TBI的剂量范围与发生辐射暴露事件时需要测量的水平直接相关。此外，DFCI正在进行的研究项目正在研究这种辐射的影响以及将暴露影响降至最低的策略。这提供了一个独特的机会，进行急需的开发和验证的方法，旨在使这种测量作为一种手段，促进有效的反应，在一个事件中，大量的人潜在地暴露于临床上显着剂量的电离辐射。DFCI的人员将与项目人员合作，对TBI患者的牙齿和指甲进行体内测量。还将获得指甲的剪报供项目2使用。当制造出适合非专业人员部署使用的原型仪器时，将在DFCI使用以前未参与仪器操作的团队成员进行测量，提供设计能力的实际测试，并提供改进原型的重要反馈。

This core will have a critically important role in all 3 projects, providing access to a population of pafients that provide a unique opportunity to develop the techniques and test the instrumentafion that is being developed. One of the potentially limiting factors in the development of accurate and effecfive biodosimetry for triage of large populations potenfially exposed to clinically significant levels of ionizing radiafion has been the lack of suitable samples and subjects to test the validity ofthe assays and to facilitate the development of the techniques. Suitable samples/subjects require exposure to ionizing radiation in the dose range leading to the acute radiation syndrome, (2 -12 Gy). It would be completely unethical to expose human individuals to such doses of radiation for the purpose of developing the methodology and evaluation in animal models is not pracfical or relevant at this stage of development. We can instead, however, utilize pafients who receive such radiafion exposures as part of their treatment for myelosuppression and immunosupression. The DFCI is one ofthe few places in the world where there are large numbers of patients who as a part of their therapy, receive TBI in the dose ranges that are direcfiy pertinent to the levels needed to be measured in the event of a radiafion exposure event. In addition, there are ongoing research programs at DFCI that are invesfigafing the effects of such irradiations and strategies to minimize the effects of the exposures. This provides a unique opportunity to carry out the much-needed development and validafion of a methodology designed to make such measurements as a means of facilitating an effecfive response to an event in which large numbers of people potenfially are exposed to clinically significant dose of ionizing radiafion. The personnel from the DFCI will work with the personnel from the projects to make measurements in the TBI patient populafion in vivo in teeth and nails. Clippings of nails also will be obtained for use by project 2. When the prototype instruments suitable for deployed use by non-expert personnel are constructed, measurements will be made at DFCI using members ofthe team that have not previously been involved with the operafion ofthe instruments, providing a realisfic test ofthe capabilifies ofthe design, with important feedback for improvement of the prototypes.