FASEB SRC on Folic Acid, Vitamin B12 and One Carbon Metabolism

描述(由申请者提供)：这项提案是为2014年8月在科罗拉多州斯普林斯举行的关于叶酸、维生素B12和一种碳代谢的FASEB SRC会议提供部分资金。这次会议有着悠久的成功历史，自1986年以来每两年举行一次。它汇集了对这些必需的B族维生素在人类健康和疾病中的作用感兴趣的科学家。这次会议是独一无二的，因为来自生物学和医学领域的许多学科和领域的科学家都参加了会议，他们对这些维生素依赖途径联合起来感兴趣。例如，研究叶酸依赖酶的博士科学家和研究该领域重要基因的分子生物学家与研究维生素缺乏症的MD临床医生、评估诊断测试的临床化学家以及负责制定与营养相关的公共政策的公共卫生科学家举行了为期5天的会议。这一群体以前参与了重要的公共卫生措施，如叶酸食品强化任务，以及调查以叶酸为基础的维生素疗法对血管疾病和痴呆症的益处。拟议的计划提供了有关这些维生素相关酶和肝脏疾病、高血压、自闭症、神经管和其他出生缺陷的代谢途径的新信息。将介绍有关强制叶酸食品强化的益处和可能的风险的信息。将讨论叶酸和维生素B12营养在母婴健康中的重要性。拟议中的会议对初级科学家来说是一个很好的培训环境，因为有机会在这一新陈代谢领域的专家之间的全国会议上展示他们的最新工作，将帮助他们找到合作伙伴，完善他们的科学方向，并在非正式的气氛中练习讲课。会议提供了许多机会，让与会者在用餐、休息、海报会议和户外娱乐设施中进行互动。这些相互作用有可能导致公共卫生领域的基本科学知识创新。

DESCRIPTION (provided by applicant): This proposal is for partial funding of a FASEB SRC conference on Folic Acid, Vitamin B12 and One Carbon Metabolism to be held in Steamboat Springs, Colorado in August, 2014. This conference has a long successful history and has been held every 2 years since 1986. It brings together scientists interested in the role of these essential B vitamins in human health and disease. This conference is unique because it is attended by scientists from many disciplines and areas of biology and medicine united in their interest in these vitamin dependent pathways. For example, PhD scientists studying folate-dependent enzymes and molecular biologists studying the genes important in this field meet for 5 days with MD clinicians studying vitamin deficiency diseases, clinical chemists evaluating diagnostic testing, and public health scientists charged with developing nutrition related public policy. This group was involved previously in important public health measures such as the folate food fortification mandate and investigations of the benefits of folate based vitamin therapy in vascular disease and dementia. The proposed program presents new information on these vitamin-related enzymes and metabolic pathways in liver diseases, hypertension, autism, neural tube and other birth defects. Information about benefits and possible risks with the mandated folate food fortification will be presented. The importance of folate and vitamin B12 nutrition in maternal-child health will be discussed. The proposed conference is an excellent training environment for junior scientists because the chance to present their latest work at a national meeting among experts in this area of metabolism will help them find collaborations, refine their scientific direction and practice lecturing in an informal atmosphere. The conference provides many opportunities to interact between attendees at meals, breaks, poster sessions and outdoor recreational facillities. These interactions have the potential to lead to basic scienc informed innovations in public health.