Analytical Core

分析核心：摘要 分析核心的目标是支持PANUC了解和治疗认知障碍的努力 帕金森病（PD）分析核心将继续提供基于实验室的数据分析， 支持所有三个PANUC项目和临床核心，以及相关的PD生物标志物计划 项目（U01 NS 082137，PI：Zhang博士，也是分析核心合作研究者）。我们将实现我们的目标， 通过以下具体目标提供两种类型的分析支持：具体目标1。实验室： 所有三个项目和临床核心的基因分析。CSF生物标志物分析：提供管理 来自临床核心的生物流体和PD和阿尔茨海默病的成熟生物标志物的分析 临床核心、项目2和链接的U01。神经病理学分析：提供组织专家分析 来自临床核心和项目1的样本。具体目标2。数据管理和统计 分析：为临床核心和所有三个方面提供专家数据管理和统计支持 项目和相关工作。该核心服务于NINDS帕金森氏症设定的多个研究优先事项 疾病2014：推进研究，改善生活。

ANALYTICAL CORE: ABSTRACT The goal of the Analytical Core is to support the efforts of PANUC to understand and treat cognitive impairment in Parkinson's disease (PD). The Analytical Core will continue providing laboratory-based and data analyses in support of all three PANUC projects and the Clinical Core, as well as to linked PD Biomarker Program project (U01 NS082137, PI: Dr. Zhang, also Analytical Core Co-Investigator). We will accomplish our goal of providing both types of analytical support through the following Specific Aims: Specific Aim 1. LABORATORY: Genetic analysis for all three projects and the Clinical Core. CSF biomarkers analysis: Provide management of biofluids from the Clinical Core and analysis of well-established biomarkers for PD and Alzheimer's disease for Clinical Core, Project 2 and the linked U01. Neuropathology analysis: Provide expert analysis of tissue samples from Clinical Core and Project 1. Specific Aim 2. DATA MANAGEMENT and STATISTICAL ANALYSIS: Provide expert data management and statistical support for the Clinical Core and all three Projects and affiliated efforts. This Core serves multiple research priorities set by the NINDS Parkinson's Disease 2014: Advancing Research, Improving Lives.