Topical Silver Sulfadiazine Formulations with Improved Efficacy and Toxicity Prof

描述（由申请人提供）：磺胺嘧啶银（SSD）是世界上使用最广泛的外用抗菌剂，虽然对多种病原体有效，但它已被证明可以延迟伤口愈合。研究表明，将固态固态盐加入天然成分添加剂中，可以显著降低配方的毒性，提高固态固态盐的溶解度，并提高药物对几种主要烧伤病原体的疗效。拟议研究的主要具体目标包括在乳膏和凝胶配方中使用不同浓度的天然添加剂制备和配方/加工SSD，测定抗菌功效，细胞相容性，并在大鼠感染烧伤模型中进行评估。提出的治疗的主要目标是：1)解决感染，2)改善愈合，和3。减少整体炎症。这种改进的局部抗菌治疗的创新和合理的方法是建立在几项不同的研究的基础上的，这些研究揭示了这种改进的和常用的治疗方法有希望的生物应用特性。该项目的最终目标是使一种或多种新型杀微生物制剂的下一阶段开发成为可能，这些新型杀微生物制剂将用于烧伤创面的治疗。

DESCRIPTION (provided by applicant): Silver Sulfadiazine (SSD) is the most widely used topical antimicrobial agent in the world and while effective against a wide variety of pathogens, i has been shown to delay wound healing. Formulation of SSD into creams and gels with the inclusion of a naturally-occurring component additive has been shown to significantly lower the toxicity of the formulation, improve the solubility of SSD, and improve the efficacy of the drug against several leading burn pathogens. The major specific aims of the proposed research involve the preparation & formulation/processing of the SSD in cream and gel formulations with varying concentrations of the naturally-occurring additive, determination of antimicrobial efficacy, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall inflammation. This innovative and rational approach to an improved topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of this improved and commonly applied therapy. The end- goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds.