Swine in Biomedical Research Conference 2014, Challenges and Opportunities

描述（由申请人提供）：2014年猪生物医学研究会议将突出猪模型在生物医学研究中日益增长的实用性。在工具箱类别中， 基于大范围核酸酶（ZFN、TALEN、CRISP/Cas）、诱导多能干细胞和下一代测序的基因编辑技术才刚刚开始受到重视。在应用类别中，除了猪在免疫学、营养学、移植、心血管疾病和整形外科方面已经证明的价值之外，还有很多东西需要探索。在人畜共患疾病、认知行为、生物工程和再生医学方面有必要采取新的举措。猪的基因组已经完成，序列信息可以用于构建模型，以开发诊断和治疗生活方式相关疾病的新方法。基因修饰和克隆猪的能力进一步提高了猪在剖析疾病机制和验证临床治疗方面的价值。美国国立卫生研究院和美国农业部都认识到需要在这一领域进行更多的研究，并通过双重目的与双重利益计划（PAR-10 - 276）合作提供资金，或宣布新的FOA专注于改善生物医学研究的动物模型，包括猪（PAR-13 - 114）。然而，需要进一步鼓励生物医学界接受这些模式，并增加临床和非临床科学家之间的互动。因此，组织这次会议是为了直接解决这些公认的局限性。首先，组委会选择了那些研究成功超越健康和动物科学文化以及临床非临床障碍的个人。其次，受邀演讲者将展示使用猪的研究，这些研究展示了成功的应用以及需要跨越拟议文化鸿沟参与的有前途的领域。最后，我们将邀请美国农业部和美国国立卫生研究院的代表领导关于整合各自优势以解决关键生物医学研究问题的讨论。

DESCRIPTION (provided by applicant): The Swine in Biomedical Research Conference 2014 will highlight the growing utility of swine models in biomedical research. In the toolbox category, gene-editing technologies based on meganucleases (ZFN, TALENs, CRISP/Cas), induced pluripotent stem cells, and next generation sequencing are just beginning to be appreciated. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are warranted in zoonotic diseases, cognitive behavior, bioengineering and regenerative medicine. The pig genome has been completed and sequence information can be used to construct models to development new means of diagnosing and treating life style-related diseases. The ability to genetically modify and clone pigs further enhances the value of the pig for dissecting disease mechanisms and validating clinical therapies. Both the NIH and the USDA have recognized the need for more research in this area and have either partnered to provide funding through the Dual Purpose with Dual Benefit Program (PAR-10-276), or have announced new FOA focused on improving animal models for biomedical research, including swine (PAR-13-114). There is, however, a need to further stimulate acceptance of these models by the biomedical community, as well as to increase the interactions between clinical and non-clinical scientists. Hence, this conference has been organized to directly address these acknowledged limitations. First, the Organizing Committee has selected individuals whose research has successfully transcended both health and animal science cultures, and clinical non-clinical barriers. Second, the invited speakers will showcase investigations using the pig that demonstrate successful applications as well as promising areas that require engagement across the proposed cultural divide. Finally, we will invite USDA and NIH representations to lead discussions on integrating respective strengths into addressing critical biomedical research issues.