National Center of Neuromodulation for Rehabilitation (NC NM4R)

项目摘要 国家神经调节康复中心（NC NM 4 R）的总体使命将是 “促进NM 4 R研究人员的成功”。NC NM 4 R试点研究的主要目的 该计划是优先考虑，提供和管理短期资金的科学价值，新的和 通过公开征集和同行评审的竞争性项目。目标是 为试点调查员提供充足的资源、支持和培训， 作为主要研究者准备竞争性校外补助金申请的初步数据， 直接利用NC NM 4 R资源中的一个或多个。该计划将重点支持NC NM 4 R子公司 (e.g.,参与NC NM 4 R研讨会和/或合作机会的研究者）， 进行原理验证或可行性研究和/或探索与其目前资助的领域不同的领域 使用NC NM 4 R支持的神经调节方法进行研究。不仅这个组件 为合格的研究人员提供试点研究计划（目标1），我们还将有广泛的 在提交之前和获奖之后与这些研究者进行互动（目标2）。 该计划将通过广泛的广告申请，每年征求试点研究申请 (RFA)在预计授标日期前五个月。RFA的分发方法包括 NC NM 4 R网站上的公告、电子通讯、向中心附属机构发布的列表服务器公告以及其他 有针对性的途径，全国范围内。提交将是基于网络的两个阶段的申请 流程包括意向书（LOI），然后在与NC互动后提交完整的申请 NM4R。应用程序将进行同行评审，并使用NIH量表进行评分，然后根据四个优先级进行排序 标准：1）研究质量（科学价值，创新和影响）; 2）与使命的相关性 研究计划中一个或多个NC NM 4 R资源的中心和直接参与; 3）资格 研究团队的领导，以确保校外资金的研究工作，和4）刺激 与NC NM 4 R研究人员合作。我们计划平均资助四个新的或有竞争力的 每年继续进行试点研究，项目期为12个月。申请人必须是合格的校长 研究者由其所在组织定义，并具备必要的技能、知识和资源， 执行拟议的工作计划;他们还必须有资格提交NIH R 01或同等PI， 他们的机构。研究人员将获得为期沿着一年的研究支持，并获得NC NM 4 R核心， 执行一个与联合国使命有关的由联合国发起的项目所需的设备和其他资源 NC NM4R。我们设想，试点研究计划将使研究人员能够形成 跨学科，互动，可持续的研究项目，将影响NM 4 R研究。

PROJECT SUMMARY The overall mission of the National Center of Neuromodulation for Rehabilitation (NC NM4R) will be “fostering the success of the NM4R researcher”. The principal objective of the NC NM4R Pilot Studies Program is to prioritize, provide and manage short-term funding for scientifically meritorious, new and innovative projects through a competitive program with open solicitation and peer review. The goal is to provide adequate resources, support and training for pilot investigators to develop sufficient preliminary data to prepare a competitive extramural grant application as Principal Investigator that will directly utilize one or more of the NC NM4R resources. The program will focus on enabling NC NM4R affiliates (e.g., investigators who have participated in NC NM4R workshops and/or collaborative opportunities) to conduct proof-of-principle or feasibility studies and/or explore an area that is distinct from their currently funded research using neuromodulatory methodologies supported by the NC NM4R. Not only will this component provide a pilot studies program for qualified researchers (Aim 1), we will also have extensive interactions with these investigators before submission and after they receive their award (Aim 2). This program will solicit pilot study applicatons annually by broadly advertising a request for applications (RFA) five months in advance of the anticipated award date. Methods of distributing the RFA will include announcements on the NC NM4R web site, e-newsletter, listserv announcements to Center affiliates and other targeted avenues with national reach. Submission will be web-based with a two-phase application process including a Letter of Intent (LOI) followed by a full application after interactions with the NC NM4R. Applications will be peer-reviewed and scored using the NIH scale, then prioritized according to four criteria: 1) quality of the research (scientific merit, innovation and impact); 2) relevance to the mission of the Center and direct involvement of one or more of the NC NM4R resources in the research plan; 3) qualifications of the research team to lead the research effort toward securing extramural funding, and 4) stimulation of collaborative efforts with NC NM4R investigators. We plan to fund an average of four new or competitive continuation pilot studies per year with 12-month project periods. Applicants must be eligible Principal Investigators as defined by their home organization and have the skills, knowledge and resources necessary to carry out the proposed work plan; they also must be eligible to submit an NIH R01 or equivalent as PI from their institution. Investigators will receive one year of research support along with access to NC NM4R cores, equipment and other resources as needed to perform an investigator-initiated project related to the mission of the NC NM4R. We envision that the Pilot Studies Program will enable investigators to form interdisciplinary, interactive, sustainable research projects that will impact NM4R research.