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A Drosophila Model Linking Diet-induced Obesity and Cancer (PQ 1)

A Drosophila Model Linking Diet-induced Obesity and Cancer (PQ 1)
将饮食引起的肥胖与癌症联系起来的果蝇模型 (PQ 1)
批准号：
8870186
负责人：
Ross Leigh Cagan
金额：
$35.17万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-08-20 至 2017-05-31
来源：
https://reporter.nih.gov/project-details/8870186
关键词：
AddressAnimal GeneticsAnimalsBiological AssayCancer ModelCarbohydratesChemicalsCollectionColon CarcinomaComplexDataDevelopmentDietDietary SucroseDietary SugarsDrosophila genusEpidemiologic StudiesFDA approvedFatty acid glycerol estersFunctional disorderGenesGenetic ScreeningGoalsHyperglycemiaIn SituInsulin ResistanceLaboratoriesLibrariesLinkMalignant NeoplasmsMalignant neoplasm of liverMalignant neoplasm of pancreasMediatingMetabolicMicroarray AnalysisModelingMolecularMolecular ProfilingMutationNeoplasm MetastasisObesityPalatePathway interactionsPharmaceutical PreparationsPropertyRiskRoboticsSeveritiesSucroseSystemTP53 geneTestingTherapeuticTissuesTumor Suppressor Genesbasecancer riskcancer typeexperiencefeedingflyinhibitor/antagonistresponsescreeningtumortumor progressiontumorigenesis

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中文摘要
翻译
描述(由申请人提供)：流行病学研究表明，癌症风险增加与肥胖有关，但其潜在机制仍然知之甚少。我们最近建立了一个果蝇肥胖模型；用高碳水化合物饮食饲养果蝇会导致代谢功能障碍，包括高血糖、胰岛素抵抗和脂肪堆积。给Ras/Src共激活的果蝇肿瘤模型喂食高蔗糖可形成侵袭性肿瘤，并以饮食依赖的方式发生紧急转移。本申请的目标是进一步利用果蝇作为有用的原位 探索饮食诱导的肥胖和肿瘤进展之间的机制联系的模型。
英文摘要
DESCRIPTION (provided by applicant): Epidemiological studies have demonstrated that increased cancer risk is associated with obesity, but the underlying mechanism remains poorly understood. We have recently developed a Drosophila model of obesity; raising Drosophila on a diet high in carbohydrates led to metabolic dysfunction including hyperglycemia, insulin-resistance and accumulation of fat. Feeding a high dietary sucrose to Ras/Src co- activated Drosophila cancer model developed aggressive tumor with emergent metastasis in a diet-dependent manner. The goal of this Application is to further utilize Drosophila as a useful in situ model to explore mechanistic link between diet-induced obesity and tumor progression.
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A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
  • 批准号：
    10908073
  • 项目类别：
  • 资助金额：
    $50.42万
  • 财政年份：
    2023
  • 负责人：
    Ross Leigh Cagan
  • 依托单位：
    SLOAN-KETTERING INST CAN RESEARCH
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A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer
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