IGF::OT::IGF SBIR TOPIC 66 PHASE II: HAPTOGLOBIN TREATMENT TO REDUCE COMPLICATIONS OF SICKLE CELL DISEASE

镰状细胞病的并发症可能通过使用触珠蛋白结合并从循环中去除游离血红蛋白来治疗。游离血红蛋白引起氧化应激和随之而来的血管和组织并发症。游离血红蛋白的结合有助于阻止游离血红蛋白进入肾脏并通过血管内皮。从循环中结合和去除游离血红蛋白的创新方法的发展可能为镰状细胞病并发症的管理提供一种新的治疗方法。

Complications of Sickle Cell Disease may potentially be treated by the use of haptoglobin to bind and remove free hemoglobin from the circulation. Free hemoglobin causes oxidative stress and attendant vascular and tissue complications. Haptoglobin binding of free hemoglobin helps prevent entry of free hemoglobin into the kidney and to pass through the vascular endothelium. The development of innovative methodologies to bind and remove free hemoglobin from the circulation may provide a novel therapeutic approach for the management of complications of Sickle Cell Disease.