TAS::75 0843::TAS HORMONE THERAPY AND COGNITIVE AGING IN OLDER AND YOUNGER POSTM

妇女健康倡议（WHI）激素治疗（HT）的随机临床试验旨在确定HT是否对绝经后妇女的健康结局，特别是心血管健康有有益的影响。无子宫的妇女被随机分配每天服用一片含有0.625 mg结合马雌激素（CEE）（倍美力，惠氏制药）或匹配安慰剂的片剂，有子宫的妇女被随机分配每天服用一片含有0.625 mg CEE和2.5 mg醋酸甲羟孕酮（MPA）（Prempro，惠氏制药）或匹配安慰剂的片剂。WHI记忆研究（WHIMS）是WHI的辅助研究，研究HT对可能的痴呆和任何认知障碍的风险以及随着时间的推移对整体认知变化的影响。联合治疗（2002年）和CEE单药治疗（2004年）的WHI和辅助WHIMS研究均早于计划停止，因为这些治疗增加了健康风险，并且不能预防冠心病。虽然停用了研究药物，但继续进行随访评估。本合同的目的是继续对WHIMS认知健康结局流行病学中的妇女进行前瞻性随访，包括痴呆症筛查和认知评估（WHIMS-ECHO）队列此外，该合同继续在最近发起的女性健康倡议年轻女性记忆研究（WHIMS-Y）中进行前瞻性认知评估，以确定长期的在WHI激素试验中随机分配年龄为50-54岁的妇女中，随机分配到绝经后HT的长期影响。WHIMS-Y测试了“机会之窗”假设，即绝经后不久的HT将有益于以后的认知健康。

The Women's Health Initiative (WHI) randomized clinical trials of hormone therapy (HT) were designed to determine whether HT had beneficial effects on health outcomes, especially cardiovascular health, in postmenopausal women. Women without uteri were randomly assigned to take one daily tablet containing either conjugated equine estrogens (CEE), 0.625 mg (Premarin, Wyeth Pharmaceuticals), or a matching placebo, and women with uteri were randomly assigned to take one daily tablet containing either CEE, 0.625 mg, and medroxy progesterone acetate (MPA), 2.5 mg, (Prempro, Wyeth Pharmaceuticals) or a matching placebo. The WHI Memory Study (WHIMS) was an ancillary to the WHI and investigated the effects of HT on risk of probable dementia and any cognitive impairment and on changes in global cognition over time. The WHI and ancillary WHIMS study were stopped earlier than planned for both the combination therapy (in 2002) and CEE-Alone (in 2004) because these treatments increased health risks and did not protect against coronary heart disease. Although study medications were discontinued, follow-up assessments continued. The purpose of the present contract is to continue prospective follow-ups, including dementia screening and cognitive assessments, of women in the WHIMS Epidemiology of Cognitive Health Outcomes (WHIMS-ECHO) cohort In addition, this contract continues prospective cognitive assessments in the more recently initiated Women's Health Initiative Memory Study of Younger Women (WHIMS-Y) to determine the long-term impact of random assignment to postmenopausal HT among women who were 50-54 years of age at the time they were randomized in the WHI hormone trials. WHIMS-Y tests the �window of opportunity� hypothesis that HT shortly after menopause will confer benefit to later cognitive health.