Investigation of processed snoRNAs as cryptic regulators of the imprinted Prader-Willi syndrome locus

Prader-Willi综合征(PWS)是一种破坏性的疾病，其症状包括智力残疾和强迫进食。当基因组的一部分被错误删除时，就会发生PWS，但为什么这一DNA很重要，目前还不清楚。我们的数据表明，被删除的DNA编码了一套以前隐藏的遗传元件，在这里，我们提议使用最新的高通量DNA和RNA测序以及干细胞技术来最终揭开这个谜团。

Prader-Willi syndrome (PWS) is a devastating disorder whose symptoms include intellectual disability and compulsive eating. PWS occurs when a piece of the genome is mistakenly deleted, but why this DNA is important is still not understood. Our data indicate that the deleted DNA encodes a suite of previously hidden genetic elements, and here we proposed using the latest high-throughput DNA and RNA sequencing and stem cell technologies to finally unravel this mystery.