Topical Microparticle Delivery for Burn Pain Control

 描述(由申请人提供)：迫切需要改进烧伤相关疼痛的治疗方法。从最初的护理到康复，烧伤后的疼痛控制是一个重大挑战。该项目的总体目标是开发一种基于止痛剂微粒的易于使用的局部给药系统，可用于治疗与深度烧伤相关的疼痛。取得进展的关键障碍之一是，目前的治疗方法除了通常不充分的止痛作用外，还存在伴随的副作用--没有可用的局部治疗方法来治疗烧伤疼痛。这种新的局部治疗方法旨在从根源上治疗疼痛，减少全身阿片类药物或其他治疗方法的使用，从而减少与当前全身治疗相关的不必要的副作用，并提高烧伤疼痛缓解的有效性。这项研究的一个关键焦点是确定哪种微粒局部给药系统具有最大的缓解烧伤疼痛的潜力。外周作用止痛药的应用旨在为烧伤相关疼痛提供有效、易用、容易和无痛的治疗。这种局部微粒传递技术有可能导致一种有市场的产品，拟议的技术将改进目前烧伤损伤和疼痛的治疗方法。第一个具体目标是将治疗剂纳入局部给药系统。第二个目的是使用生物人造真皮系统评估药物的体外释放特性。第三个具体目标是利用临床烧伤和科学疼痛专家团队选择TH配方进行体内测试。第四个具体目标是使用啮齿动物烧伤模型在体内评估优化后的给药系统的效果。由此产生的产品被设计成一种独特的局部给药系统，可以用于无痛地对烧伤疼痛进行止痛治疗。这项研究的影响是帮助数百万受害者，其中许多是儿童和受伤的战士，他们因烧伤而产生令人衰弱的急性和慢性疼痛。

 DESCRIPTION (provided by applicant): There is a critical need for improved treatments for pain associated with burn injury. Pain control after burn injury is a major challenge from the initial point of care through rehabilitation. The overall objective of this project is to develop a easily-applied topical delivery system based on analgesic microparticles that can be used for treatment of pain associated with deep partial thickness burns. One of the critical barriers to progress is that current therapies are administered systemically with concomitant side effects in addition to often insufficient pain relief - no topical treatments are available to treat burn pain This new topical treatment approach is designed to target pain at the source, lowering usage of systemic opioids or other treatments, thus reducing unwanted side effects associated with the current systemic treatments and enhancing the effectiveness of burn pain relief. A key focus of this research is to determine which microparticle topical delivery system has the highest potential for burn pain relief. The application of peripherally-acting analgesics has been designed to provide effective, simple-to-use, easily and painlessly applied treatment of pain associated with burn injury. This topical microparticle delivery technology has the potential to lead to a marketable product and the proposed technology will improve current treatment methodologies for burn injury and pain. The first specific aim is to incorporate therapeutic agents into the topical delivery system. The second aim is to evaluate drug release characteristics ex vivo using a bioartificial dermis system. The third specific aim is to select th formulation for in vivo testing utilizing a team of clinical burn and scientific pain experts. The fourth specific aim is to evaluate the efficacy of the optimized delivery system in vivo using a rodent burn model. The resulting product is being designed to be a unique topical delivery system that can be used to painlessly apply analgesic treatment for burn pain. The impact of this research is to help the millions of victims, many of whom are children and wounded warriors, who have debilitating acute and chronic pain resulting from burns.