Statistical Methods In Human Development/clinical Studies

基于几年前在当地学区完成的一项病例对照研究，我们正在继续调查ADHD可能的环境风险因素。在正在进行的工作中，我们正在研究ADHD的社会经济地位和父母病史作为可能的危险因素。(见Z01 ES49034；PiDale Sandler，EB) 在正在进行的肌萎缩侧索硬化症的研究工作中，我们正在研究军事和职业暴露作为疾病的危险因素，以及它们对确诊后生存的可能影响。这项正在进行的工作是与杜克大学和达勒姆退伍军人管理医院的研究人员合作，使用来自美国退伍军人的病例对照研究数据。(见Z01 ES49005；Li Freya Kamel，EB) 我们进行了一项嵌套在农业健康研究中的病例对照研究，以检查帕金森氏病与环境风险因素之间的关系，特别是某些农药暴露。我们也在研究选定的候选基因作为易感因素。这项研究使用了农业健康研究的数据，以及专门为这项工作收集的其他问卷数据和实地样本。最近，我们报道了编码肽聚糖识别蛋白的基因的多态与帕金森病有关。我们还在研究个人防护装备的使用是否会改变某些杀虫剂与帕金森氏症之间的联系。这项研究的数据分析正在进行中。(见Z01 ES44007 EB；Li Freya Kamel，EB) 在其他工作中，我们使用了社区动脉粥样硬化风险研究的数据来检查血浆胆固醇和他汀类药物的使用对帕金森病风险的作用。我们的结论是，总胆固醇水平越高，风险越低，而他汀类药物的使用与风险越高。我们还使用了来自NIH-AARP饮食和健康研究的数据来观察饮食脂肪摄入量和帕金森病风险之间的潜在联系。我们的结果表明，摄入较多的N-6多不饱和脂肪酸与患帕金森病的风险略高有关。(见Z01 ES101986 EB；PiHong Ley Chen，EB) 在费城儿童医院进行的大豆雌激素对新生儿发育影响的研究的数据收集现在已经完成。我们目前正在与两个商业实验室和疾病预防控制中心合作，以解决实验室之间在睾酮测量方面的一些差异。我们已经发表了一篇论文，描述了婴儿阴道和尿路上皮细胞学评估方法的表现。正在进行的分析旨在发现大豆喂养的婴儿与母乳或牛奶喂养的婴儿在可能受雌激素影响的解剖特征的年龄轨迹上的差异。(见Z01 ES44006 EB；Pi Walter Rogan，EB) 最近的一项工作使用了挪威医学出生登记处的数据来估计患有和不患有先兆子痫的母亲中特定胎龄的死产风险。

Based on a case-control study completed several years ago in a local school district, we are continuing to investigate possible environmental risk factors for ADHD. In ongoing work, we are looking at socioeconomic status and parental history of ADHD as a possible risk factors. (see Z01 ES49034; PI Dale Sandler, EB) In ongoing work on ALS, we are examining military and occupational exposures as risk factors for the diease and for their possible effects on survival after diagnosis. This ongoing work is in collaboration with researchers at Duke University and the Durham Veterans Administration Hospital using data from a case-control study of U.S. veterans. (see Z01 ES49005; LI Freya Kamel, EB) We have carried out a case-control study nested within the Agricultural Health Study to examine associations between Parkinson's disease and environmental risk factors, particularly certain pesticide exposures. We are also looking at selected candidate genes as susceptibility factors. This study employs data from the Agricultural Health Study as well as additional questionnaire data and field samples collected expressly for this effort. Recently, we reported that polymorphisms in genes coding for peptidoglycan recognition proteins are associated with Parkinson's disease. We are also examining whether the use of personal protective equipment modifies the association between certain pesticides and Parkinson's disease. Analysis of data from this study is ongoing. (see Z01 ES44007 EB; LI Freya Kamel, EB) In other work, we have used data from the Atherosclerosis Risk in Communities Study to examine the role of plasma cholesterol and statin-use on the risk of Parkinson's disease. We concluded that higher levels of total cholesterol were associated with a lower risk whereas statin use was associated with a higher risk. We also used data from the NIH-AARP Diet and Health Study to look at potential associations between dietary fat intake and the risk of Parkinsons disease. Our results suggested that higher intake of N-6 polyunsaturated fatty acids is associated with a slightly higher risk of PD. (see Z01 ES101986 EB; PI Honglei Chen, EB) Data collection for a study of the effects of soy estrogen on neonatal development carried out at Childrens Hospital of Philadelphia is now complete. We are currently working with two commercial laboratories and the CDC to resolve some inter-laboratory differences in testosterone measurements. We have published a paper characterizing the performance of methods for cytological assessment of vaginal and urethral epithelium in infants. Ongoing analyses are directed a finding differences between soy-fed infants and breast-milk or cow-milk fed infants in the age trajectories of anatomical features that are likely influenced by estrogen. (see Z01 ES44006 EB; PI Walter Rogan, EB) A recent effort used data from the Medical Birth Registry of Norway to estimate the gestational-age-specific risk of stillbirth among mothers with and without preeclampsia.