Human Samples: Core C

摘要 人类样本核心C将负责：1)临床样本和肺部样本的收集和准备 标本；2)在人类原代上皮细胞中评估候选疫苗；以及3)测量血清 人和棉鼠样本中的RSV抗体。它将支持所有4个项目并与之互动 动物核心B包括在本P01中。因此，这一核心将服务于两个主要目标。首先，它将保证质量 人类样本，它将简化样本组织、数据管理和合规性 遵守所有的规定。其次，这个核心将负责：a)运行体外原代细胞培养试验 评估项目1、2和3产生的候选疫苗；以及b)在 从项目4中的婴儿和棉鼠的实验性感染中获得的血清样本 在动物核心B执行。这种方法将优化资源的使用，并将促进整合 以及所有项目之间的协同效应。

Abstract The Human Sample Core C will be responsible for: 1) collection and preparation of clinical samples and lung specimens; 2) evaluation of vaccine candidates in human primary epithelial cells; and 3) measuring serum RSV antibodies from human and cotton rat samples. It will support and interact with all 4 Projects and the Animal Core B included in this P01. Thus, this Core will serve two main goals. First, it will assure the quality of the human samples, and it will simplify streamlining sample organization, data management and compliance with all regulations. Second, this core will be responsible for: a) running the in vitro primary cell culture assays to evaluate vaccine candidates generated by Projects 1, 2 and 3; and b) measuring serum RSV antibodies in serum samples obtained from infants included in Project 4 and from experimental infections in cotton rats performed in the Animal Core B. This approach will optimize the use of resources and will facilitate integration and synergy among all projects.