Development of novel agents for the treatment of renal fibrosis

描述（由申请人提供）：我们项目的最终目标是开发新的治疗方法，有效治疗慢性肾脏疾病，这些疾病通常发展为纤维化，导致终末期肾脏疾病，需要肾脏替代治疗。SBIR 2期申请建立在1期获得的结果基础上，其中发现了新的选择性小分子拮抗剂，可防止单侧输尿管梗阻肾纤维化的进展

DESCRIPTION (provided by applicant): The ultimate goal of our project is to develop novel therapeutics effective in chronic kidney diseases that normally develop fibrosis, lead to end stage renal disease and require renal replacement therapy. This SBIR phase 2 application builds on the results obtained in phase 1 where novel and selective small molecule antagonists were discovered that prevent the progression of renal fibrosis in a unilateral ureteral obstruction (UUO) animal model. Leads identified in phase 1 will be optimized for drug-like and ADME properties. Candidate compounds meeting the selection criteria will be assessed for safety in vivo and the best compound will be examined in several different animal models of chronic kidney disease to delineate a development path in the clinical setting.