Aspen Lung Conference: Rebuilding the Injured Lung

描述(申请人提供)：第57届Thomas L.Petty Aspen肺会议将聚焦一个核心问题：如何将有关肺泡损伤潜在机制的知识转化为重建受损肺的有效方法，重点是基础、转换和临床方法的整合。为了解决这一核心问题，我们将会议安排为一系列主题会议，重点是(I)对急性进行性肺损伤和纤维化的致病机制的当代理解，(Ii)围绕肺上皮细胞、间充质细胞和周围细胞外结缔组织基质之间复杂相互作用的概念性问题，(Iii)作为修复和重建受损肺的方法的基质支架和干细胞生物学的当前理解，同时防止纤维化肺疾病的发展或进展，以及(Iv)将科学进步转化为肺损伤和/或纤维化患者的潜在治疗方法的策略。通过在六个主题会议上讨论这些主题，我们寻求实现以下目标：1)为领先的基础、翻译和临床研究人员提供一个国际论坛，就导致肺损伤、纤维化和修复的基本概念交换意见。2)促进历史上不同的急性肺损伤/急性呼吸窘迫综合征和肺纤维化科学领域之间的互动，目的是确定可能导致更有效和更有成效的研究成果的新的、共同的兴趣。3)通过开发新的战略来更好地将科学进步落实到患者护理中，并通过解决临床试验设计中的挑战，提高将临床前科学进步转化为直接患者利益的成功可能性。4)挑战和激发学员的科学兴趣，吸引新一代初级调查人员进入肺损伤和修复领域。

DESCRIPTION (provided by applicant): With an emphasis on the integration of basic, translational and clinical approaches, the 57th annual Thomas L. Petty Aspen Lung Conference will focus on a central question: how can we translate knowledge regarding the mechanisms underlying alveolar injury into effective approaches to rebuild the injured lung? To address this central question, we have organized the conference program into a series of thematic sessions focusing on (i) contemporary understanding of the pathogenic mechanisms underlying acute and progressive lung injury and fibrosis, (ii) conceptual issues centering around the complex interactions between pulmonary epithelial cells, mesenchymal cells, and the surrounding extracellular connective tissue matrix, (iii) current understanding of matrix scaffolds and stem cell biology as approaches to repairing and rebuilding the injured lung, while preventing the development or progression of fibrotic lung disease, and (iv) strategies to translate scientific advances into potential therapies for patients with lung injury and/or fibrosis. By addressing these topics across six thematic sessions, we seek to accomplish the following objectives: 1) To provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding fundamental concepts contributing to lung injury, fibrosis, and repair. 2) To stimulate interactions between the historically-disparate scientific fields of Acute Lung Injury/ARDS and Pulmonary Fibrosis with the goal of identifying emerging, shared interests that may lead to the performance of more efficient and productive research. 3) To enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better implement scientific advances into patient care and by addressing challenges in clinical trial design. 4) To challenge and stimulate the scientific interests of trainees, attracting a new generation of junior investigators into the fields of lung injury and repair.