Genetically engineered mouse models

项目总结(见说明)： 基因工程小鼠(GEIVI)品系的利用是GTBT P01计划项目的一个组成部分。小鼠模型核心将提供所有必要的专业知识、试剂和服务，以分析在GEM模型的GBM治疗应用方面的外体生物学。该中心提供的服务和试剂将与个别项目协同工作，以验证和评估与胞外体相关的分子生物标记物，并应用尖端监测技术来监测肿瘤对治疗剂的反应。此外，核心将在资助期间生产和表征三个新的GBM创业板品种。因此，Core将支持构建这些新的转基因小鼠模型的方方面面，包括为每个特定品系的优化设计和构建提供建议、服务、技术和试剂。使用这些新菌株，核心还将评估和实施与个别项目密切相关的各种外体指标的检测和监测新技术。

PROJECT SUMMARY (See instructions): The utilization of genetically engineered mouse (GEIVI) strains is an integral component of this GTBT P01 program project. The mouse model Core will provide all the necessary expertise, reagents and services for the analysis of exosomal biology with regards to therapeutic applications in GEM models of GBM. The services and reagents provided by this Core will synergize with the individual Projects on the validation and assessment of exosomal-associated molecular biomarkers and the application of cutting edge monitoring technologies for tumor response to therapeutic agents. In addition, the Core will produce and characterize three new GBM GEM strains over the funding period. As such, the Core will support all aspects of the construction of these new transgenic mouse models, including advice, service, technologies and reagents for the optimal design and construction of each specific strain. Using these new strains, the Core will also evaluate and implement new technologies for the detection and monitoring of various exosomal metrics in close relationship with the individual Projects.