Training in Orthopaedic Researchhttps://apps.era.nih.gov/grantfolder/viewInternalGF.era?applId=8841318&folderId=90

描述（由申请人提供）：罗彻斯特大学医学中心肌肉骨骼研究中心骨科研究培训项目在2006年至今的第一个资助期内蓬勃发展。从25名参与培训的教师发展到29名，来自8个系、部和中心，并在初期成功招募了一批学生和博士后。该计划的使命仍然是：提供肌肉骨骼科学的全面培训，旨在培养骨科研究领域的杰出研究者。6-10年的项目包括6名博士预科生和2名博士后实习生的培训名额，并围绕这些实习生制定了一个教育计划，提供对骨科研究的全面理解。培训经验旨在培养从最基本的分子研究到人体临床试验的设计和执行等领域的能力，强调研究转化的概念。该中心和相关的培训教师代表了一个高度整合的导师群体，在7个核心研究重点领域提供研究培训机会：骨细胞生物学，软骨生物学和骨关节炎，炎症性骨病，骨骼修复，骨癌，骨骼发育和肌肉骨骼临床试验。被接受的博士预科生进入生物医学科学研究生教育（GEBS）项目，该中心已成为一个受欢迎的目的地，目前有19名学生正在攻读博士学位。此外，中心目前还支持16名博士后的高级培训。为了完成我们的使命，中心制定了一个由6个核心活动支持的教育计划：1)中心范围内的实验室会议（每年6次学员演讲），2)全面的骨科科学基础课程，包括3个旋转模块的讲座，重点是方法论，基本骨骼生物学/病理学和“科学艺术”（例如拨款和论文写作，有效演示，道德），3)两个持续运行的期刊俱乐部，4)一个拨款写作核心，5)一个客座教授系列研讨会和6)一个年度肌肉骨骼研究中心研讨会，并邀请一位主讲人。在最初的资助期间，我们能够优化这些核心活动的功能，现在，甚至比以前更有能力吸引优秀的年轻科学家加入这个项目。总的来说，我们的目标是让他们参与我们的项目，成为他们发展成为能够将未来的基本发现转化为有效的人类治疗的互动骨科研究者的基石。

DESCRIPTION (provided by applicant): The Training Program in Orthopaedic Research in the Center for Musculoskeletal Research at the University of Rochester Medical Center has thrived during its first funding period from 2006-present. It has grown from 25 to 29 participating training faculty from 8 Departments, Divisions and Centers and it has recruited a successful group of students and post-doctoral fellows during this initial period. The mission of the program continues to be: To provide comprehensive training in musculoskeletal science with the aim of developing outstanding investigators in the field of orthopaedic research. The program for years 6-10 contains training slots for 6 pre-doctoral and 2 post-doctoral trainees and around these trainees is developed an education program that provides a comprehensive understanding of orthopaedic investigation. The training experience aims to build competency in areas ranging from the most basic molecular studies to the design and execution of human clinical trials, stressing the concept of research translation. The Center and associated training faculty represent a highly integrated group of mentors that provide research training opportunities in 7 core research focus areas: bone cell biology, cartilage biology & osteoarthritis, inflammatory bone disease, skeletal repair, bone cancer, skeletal development and musculoskeletal clinical trials. Accepted pre-doctoral trainees matriculate into the Graduate Education in the Biomedical Sciences (GEBS) program, and the Center has become a popular destination with 19 students currently working toward their PhD. In addition, the Center currently supports the advanced training of 16 post-doctoral trainees. To accomplish our stated mission, the Center has developed an education program supported by 6 core activities: 1) Center-wide lab meetings (6 trainee presentations/year), 2) A comprehensive Foundations of Orthopaedic Science Curriculum that is comprised of 3 rotating blocks of lectures focused on methodology, basic skeletal biology/pathology, and the 'Art of Science' (e.g. grant and paper writing, effective presenting, ethics), 3) Two continuously running Journal Clubs, 4) A Grant Writing Core, 5) A visiting professor seminar series and 6) An annual Center for Musculoskeletal Research Symposium with an invited keynote speaker. During the initial funding period, we were able to optimize the function of these Core Activities and are now, even more then before, positioned to attract outstanding young scientists to the program. Overall, we aim to make their involvement in our program the cornerstone to their development into interactive orthopaedic investigators skilled to translate the basic discoveries of the future into effective human therapies.