Octet Red 384 for multi-disciplinary studies

描述（由申请人提供）：生物分子相互作用是生物学各个方面的基础。Octet RED 384仪器能够扩展研究人员测量和动力学表征生物分子相互作用的能力。与以前的生物分子相互作用仪器相比，Octet RED 384的通量能力增加，使研究人员能够大大扩展可以测量的相互作用的数量和类型。将使用该仪器的研究人员来自广泛的科学学科，包括生物医学工程，化学，药理学，生物化学和生物学。研究人员将追求的应用实例包括药物洗脱支架的开发、神经元信号事件的建模、细胞内递送的开发、癌症信号蛋白的分子机制、红细胞功能和宿主-疟原虫关系。所有这些项目都涉及蛋白质-蛋白质、蛋白质-RNA和蛋白质-小分子相互作用的研究，这些都可以通过仪器进行测量。测量这些相互作用的能力对于加速研究人员的研究目标非常重要，这些目标包括从理解疾病状态的基本生物学机制到转化医学。

DESCRIPTION (provided by applicant): Biomolecular interactions are the foundation for all aspects of biology. The Octet RED384 instrument is capable of expanding the ability of researchers to measure and kinetically characterize biomolecular interactions. The increased throughput ability of the Octet RED384, compared to previous biomolecular interaction instruments, allows investigators to greatly expand the number and type of interactions that can be measured. The investigators who will use this instrument are drawn from broad disciplines of science including biomedical engineering, chemistry, pharmacology, biochemistry and biology. Examples of applications that will be pursued by the investigators include development of drug-eluting stents, modeling of neuronal signaling events, development of intracellular delivery, molecular mechanisms of cancer signaling proteins, erythrocyte function and the host-malaria parasite relationship. All of these projects involve the investigation of protein-protein, protein-RNA and protein-small molecule interactions, which can all be measured by the instrument. The ability to measure these interactions is important in accelerating the investigators research goals, which range from understanding basic biological mechanisms underlying disease states to translational medicine.