Investigation of SYD-1 function in axon guidance.

 描述(由申请人提供)：轴突通过对细胞外引导信号的定向反应而通过发育中的神经系统。轴突同时暴露在多个引导线索中，必须整合这些信息以提供统一的反应。在识别受体和信号通路方面已经取得了很大进展。然而，关于轴突如何整合来自不同引导信号通路的信息，我们知道的要少得多。我们的初步数据表明SYD-1参与轴突引导。我们将检验这一假设，即SYD-1可以介导UNC-6独立的UNC-40信号，以促进对SLT-1指导线索的反应。此外，我们还将描述SYD-1调节轴突引导的机制。支持我们的假设意义重大，因为它将为UNC-40和SAX-3信号通路之间的串扰提供一种机制，从而为指导信号通路之间的信息如何整合提供洞察。

 DESCRIPTION (provided by applicant): Axons are guided through the developing nervous system by directional responses to extracellular guidance cues. The axon is simultaneously exposed to multiple guidance cues and must integrate this information to provide a unified response. Much progress has been made in identifying receptors and signaling pathways. However, much less is known about how the axon integrates information from the different guidance signaling pathways. Our preliminary data implicate SYD-1 in axon guidance. We will test the hypothesis that SYD-1 can mediate UNC-6 independent UNC-40 signaling to promote the response to the SLT-1 guidance cue. In addition, we will characterize the mechanism through which SYD-1 regulates axon guidance. Support for our hypothesis would be significant because it would provide a mechanism for crosstalk between the UNC-40 and SAX-3 signaling pathways, thereby providing insight into how information between guidance signaling pathways can be integrated.